High frequency of the HIV-1 protective CCR5 Δ32 deletion in native Estonians

被引：20

作者：

Kalev, I ^{[1
]}

Mikelsaar, AV ^{[1
]}

Beckman, L ^{[1
]}

Tasa, G ^{[1
]}

Pärlist, P ^{[1
]}

机构：

[1] Univ Tartu, Inst Gen & Mol Pathol, Dept Human Biol & Genet, Tartu, Estonia

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2000年 / 16卷 / 12期

关键词：

CCR5; gene; Estonians; genetic polymorphism; human CC chemokine receptor 5; population study;

D O I：

10.1023/A:1010829816334

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In previous studies, the highest frequencies (16%) of the CCR5 Delta 32 deletion have been found in populations of Finno-Ugric origin. We here report a high CCR5 Delta 32 frequency (15%) in another Finno-Ugric populations, the Estonians. The highest frequency (18%) was found on the geographically isolated Estonian island of Dago. We examined 504 healthy unrelated individuals of Estonian nationality, whose grandparents were born in Estonia. The polymerase chain reaction assay was performed and the amplified products were digested with EcoRI.

引用

页码：1107 / 1109

页数：3

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