Technical note: Commissioning of a linear accelerator producing ultra-high dose rate electrons

被引:5
|
作者
Cetnar, Ashley J. [2 ,3 ]
Jain, Sagarika [1 ]
Gupta, Nilendu [1 ]
Chakravarti, Arnab [1 ]
机构
[1] James Canc Hosp, Dept Radiat Oncol, Columbus, OH USA
[2] James Canc Hosp, Dept Radiat Oncol, 460 W 10th Ave,Suite A201F, Columbus, OH 43210 USA
[3] Ohio State Univ, Solove Res Inst, 460 W 10th Ave,Suite A201F, Columbus, OH 43210 USA
关键词
commissioning; flash; linac; ultra high dose rate; FLASH RADIATION-THERAPY; BEAM DOSIMETRY; IRRADIATION; VALIDATION; SIMULATION;
D O I
10.1002/mp.16925
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Ultra-high dose rate radiation (UHDR) is being explored by researchers in promise of advancing radiation therapy treatments.Purpose: This work presents the commissioning of Varian's Flash Extension for research (FLEX) conversion of a Clinac to deliver UHDR electrons.Methods: A Varian Clinac iX with the FLEX conversion was commissioned for non-clinical research use with 16 MeV UHDR (16H) energy. This involved addition of new hardware, optimizing the electron gun voltages, radiofrequency (RF) power, and steering coils in order to maximize the accelerated electron beam current, sending the beam through custom scattering foils to produce the UHDR with 16H beam. Profiles and percent depth dose (PDD) measurements for 16H were obtained using radiochromic film in a custom vertical film holder and were compared to 16 MeV conventional electrons (16C). Dose rate and dose per pulse (DPP) were calculated from measured dose in film. Linearity and stability were assessed using an Advanced Markus ionization chamber.Results: Energies for 16H and 16C had similar beam quality based on PDD measurements. Measurements at the head of the machine (61.3 cm SSD) with jaws set to 10x10 cm(2) showed the FWHM of the profile as 7.2 cm, with 3.4 Gy as the maximum DPP and instantaneous dose rate of 8.1E5 Gy/s. Measurements at 100 cm SSD with 10 cm standard cone showed the full width at half max (FWHM) of the profile as 10.5 cm, 1.08 Gy as the maximum DPP and instantaneous dose rate of 2.E5 Gy/s. Machine output with number of pulses was linear (R = 1) from 1 to 99 delivered pulses. Output stability was measured within +/- 1% within the same session and within +/- 2% for daily variations.Conclusions: The FLEX conversion of the Clinac is able to generate UHDR electron beams which are reproducible with beam properties similar to clinically used electrons at 16 MeV. Having a platform which can quickly transition between UHDR and conventional modes (<1 min) can be advantageous for future research applications.
引用
收藏
页码:1415 / 1420
页数:6
相关论文
共 50 条
  • [1] Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation
    Lempart, Michael
    Blad, Borje
    Adrian, Gabriel
    Back, Sven
    Knoos, Tommy
    Ceberg, Crister
    Petersson, Kristoffer
    RADIOTHERAPY AND ONCOLOGY, 2019, 139 : 40 - 45
  • [2] Characterization of a Modified Clinical Linear Accelerator for Ultra-High Dose Rate Beam Delivery
    Deut, Umberto
    Camperi, Aurora
    Cavicchi, Cristiano
    Cirio, Roberto
    Data, Emanuele Maria
    Durisi, Elisabetta Alessandra
    Ferrero, Veronica
    Ferro, Arianna
    Giordanengo, Simona
    Villarreal, Oscar Marti
    Mas Milian, Felix
    Medina, Elisabetta
    Olivares, Diango M. Montalvan
    Mostardi, Franco
    Monti, Valeria
    Sacchi, Roberto
    Salmeri, Edoardo
    Vignati, Anna
    APPLIED SCIENCES-BASEL, 2024, 14 (17):
  • [3] Enabling ultra-high dose rate electron beams at a clinical linear accelerator for isocentric treatments
    Dal Bello, Riccardo
    von der Grun, Jens
    Fabiano, Silvia
    Rudolf, Thomas
    Saltybaeva, Natalia
    Stark, Luisa S.
    Ahmed, Md
    Bathula, Manohar
    Dogan, Serpil Kucuker
    McNeur, Joshua
    Guckenberger, Matthias
    Tanadini-Lang, Stephanie
    RADIOTHERAPY AND ONCOLOGY, 2023, 187
  • [4] Development of dosimetric procedures for experimental ultra-high dose rate irradiation at a clinical linear accelerator
    Konradsson, E.
    Petersson, K.
    Adrian, G.
    Lempart, M.
    Blad, B.
    Ceberg, S.
    Knoos, T.
    Back, S. A. J.
    Ceberg, C.
    11TH INTERNATIONAL CONFERENCE ON 3D RADIATION DOSIMETRY, IC3DDOSE, 2022, 2167
  • [5] Autoresonant ultra-high frequency accelerator of electrons
    Protasevich, E.T.
    Pribory i Tekhnika Eksperimenta, 1994, (01): : 137 - 143
  • [6] Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility
    Garty, Guy
    Obaid, Razib
    Deoli, Naresh
    Royba, Ekaterina
    Tan, Yuewen
    Harken, Andrew D.
    Brenner, David J.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [7] Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility
    Guy Garty
    Razib Obaid
    Naresh Deoli
    Ekaterina Royba
    Yuewen Tan
    Andrew D. Harken
    David J. Brenner
    Scientific Reports, 12
  • [8] VHEE beam dosimetry at CERN Linear Electron Accelerator for Research under ultra-high dose rate conditions
    Poppinga, Daniela
    Kranzer, Rafael
    Farabolini, Wilfrid
    Gilardi, Antonio
    Corsini, Roberto
    Wyrwoll, Vanessa
    Looe, Hui Khee
    Delfs, Bjorn
    Gabrisch, Lukas
    Poppe, Bjorn
    BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 2021, 7 (01)
  • [9] Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator
    Schuler, Emil
    Trovati, Stefania
    King, Gregory
    Lartey, Frederick
    Rafat, Marjan
    Villegas, Manuel
    Praxel, A. Joe
    Loo, Billy W., Jr.
    Maxim, Peter G.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 97 (01): : 195 - 203
  • [10] Feasibility of Clinically Practical Ultra-High Dose Rate (FLASH) Radiation Delivery by a Reversible Configuration of a Standard Clinical-Use Linear Accelerator
    No, H. J.
    Wu, Y. F.
    Manjappa, R.
    Skinner, L.
    Lau, B.
    Melemenidis, S.
    Yu, S. J.
    Surucu, M.
    Schueler, E.
    Bush, K.
    Graves, E. E.
    Maxim, P. G.
    Loo, B. W., Jr.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2021, 111 (03): : S32 - S32