Technical note: Commissioning of a linear accelerator producing ultra-high dose rate electrons

被引:5
|
作者
Cetnar, Ashley J. [2 ,3 ]
Jain, Sagarika [1 ]
Gupta, Nilendu [1 ]
Chakravarti, Arnab [1 ]
机构
[1] James Canc Hosp, Dept Radiat Oncol, Columbus, OH USA
[2] James Canc Hosp, Dept Radiat Oncol, 460 W 10th Ave,Suite A201F, Columbus, OH 43210 USA
[3] Ohio State Univ, Solove Res Inst, 460 W 10th Ave,Suite A201F, Columbus, OH 43210 USA
关键词
commissioning; flash; linac; ultra high dose rate; FLASH RADIATION-THERAPY; BEAM DOSIMETRY; IRRADIATION; VALIDATION; SIMULATION;
D O I
10.1002/mp.16925
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Ultra-high dose rate radiation (UHDR) is being explored by researchers in promise of advancing radiation therapy treatments.Purpose: This work presents the commissioning of Varian's Flash Extension for research (FLEX) conversion of a Clinac to deliver UHDR electrons.Methods: A Varian Clinac iX with the FLEX conversion was commissioned for non-clinical research use with 16 MeV UHDR (16H) energy. This involved addition of new hardware, optimizing the electron gun voltages, radiofrequency (RF) power, and steering coils in order to maximize the accelerated electron beam current, sending the beam through custom scattering foils to produce the UHDR with 16H beam. Profiles and percent depth dose (PDD) measurements for 16H were obtained using radiochromic film in a custom vertical film holder and were compared to 16 MeV conventional electrons (16C). Dose rate and dose per pulse (DPP) were calculated from measured dose in film. Linearity and stability were assessed using an Advanced Markus ionization chamber.Results: Energies for 16H and 16C had similar beam quality based on PDD measurements. Measurements at the head of the machine (61.3 cm SSD) with jaws set to 10x10 cm(2) showed the FWHM of the profile as 7.2 cm, with 3.4 Gy as the maximum DPP and instantaneous dose rate of 8.1E5 Gy/s. Measurements at 100 cm SSD with 10 cm standard cone showed the full width at half max (FWHM) of the profile as 10.5 cm, 1.08 Gy as the maximum DPP and instantaneous dose rate of 2.E5 Gy/s. Machine output with number of pulses was linear (R = 1) from 1 to 99 delivered pulses. Output stability was measured within +/- 1% within the same session and within +/- 2% for daily variations.Conclusions: The FLEX conversion of the Clinac is able to generate UHDR electron beams which are reproducible with beam properties similar to clinically used electrons at 16 MeV. Having a platform which can quickly transition between UHDR and conventional modes (<1 min) can be advantageous for future research applications.
引用
收藏
页码:1415 / 1420
页数:6
相关论文
共 50 条
  • [21] The dresden platform is a research hub for ultra-high dose rate radiobiology
    Metzkes-Ng, Josefine
    Brack, Florian-Emanuel
    Kroll, Florian
    Bernert, Constantin
    Bock, Stefan
    Bodenstein, Elisabeth
    Brand, Michael
    Cowan, Thomas E.
    Gebhardt, Rene
    Hans, Stefan
    Helbig, Uwe
    Horst, Felix
    Jansen, Jeannette
    Kraft, Stephan D.
    Krause, Mechthild
    Lessmann, Elisabeth
    Loeck, Steffen
    Pawelke, Joerg
    Pueschel, Thomas
    Reimold, Marvin
    Rehwald, Martin
    Richter, Christian
    Schlenvoigt, Hans-Peter
    Schramm, Ulrich
    Schuerer, Michael
    Seco, Joao
    Szabo, Emilia Rita
    Umlandt, Marvin E. P.
    Zeil, Karl
    Ziegler, Tim
    Beyreuther, Elke
    SCIENTIFIC REPORTS, 2023, 13 (01):
  • [22] Development of Ultra-High Dose-Rate (FLASH) Particle Therapy
    Kim, Michele M.
    Darafsheh, Arash
    Schuemann, Jan
    Dokic, Ivana
    Lundh, Olle
    Zhao, Tianyu
    Ramos-Mendez, Jose
    Dong, Lei
    Petersson, Kristoffer
    IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, 2022, 6 (03) : 252 - 262
  • [23] Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector
    Liu J.
    Yu X.
    Wu C.
    Sun X.
    Shang H.
    Liao W.
    Yan N.
    Zhou Y.
    Pu Y.
    He Jishu/Nuclear Techniques, 2023, 46 (11):
  • [24] HIGH CURRENT LINEAR INDUCTION ACCELERATOR FOR ELECTRONS
    CHRISTOFILOS, NC
    LAMB, WAS
    WRIGHT, RE
    HESTER, RE
    REAGAN, DD
    SHERWOOD, WA
    REVIEW OF SCIENTIFIC INSTRUMENTS, 1964, 35 (07): : 886 - &
  • [25] Radiation damage and recovery of plastic scintillators under ultra-high dose rate 200 MeV electrons at CERN CLEAR facility
    Giguere, Cloe
    Hart, Alexander
    Bateman, Joseph
    Korysko, Pierre
    Farabolini, Wilfrid
    Lechasseur, Yoan
    Bazalova-Carter, Magdalena
    Beaulieu, Luc
    PHYSICS IN MEDICINE AND BIOLOGY, 2025, 70 (07):
  • [26] Commissioning of a clinical pencil beam scanning proton therapy unit for ultra-high dose rates (FLASH)
    Nesteruk, Konrad P.
    Togno, Michele
    Grossmann, Martin
    Lomax, Anthony J.
    Weber, Damien C.
    Schippers, Jacobus M.
    Safai, Sairos
    Meer, David
    Psoroulas, Serena
    MEDICAL PHYSICS, 2021, 48 (07) : 4017 - 4026
  • [27] Oxygen Enhances Plasmid DNA Damage at Ultra-High Dose Rate More Than Conventional Dose Rate
    Thomas, W. S.
    Kulkarni, S. S.
    Pogue, B. W.
    MEDICAL PHYSICS, 2024, 51 (09) : 6587 - 6587
  • [28] Real-time Plastic Scintillation Dosimetry of Ultra-High Dose Rate Very High Energy Electrons (VHEE) at CERN CLEAR Facility
    Giguere, Cloe
    Hart, Alexander
    Bateman, Joseph
    Korysko, Pierre
    Farabolini, Wilfrid
    LeChasseur, Yoan
    Bazalova-Carter, Magdalena
    Beaulieu, Luc
    13TH INTERNATIONAL CONFERENCE ON 3D DOSIMETRY, IC3DDOSE 2024, 2024, 2799
  • [29] Research and Development for Ultra-High Gradient Accelerator Structures
    Tantawi, Sami G.
    Dolgashev, Valery
    Higashi, Yasuo
    Spataro, Bruno
    ADVANCED ACCELERATOR CONCEPTS, 2010, 1299 : 29 - +
  • [30] Characterization of a ultra-high dose rate proton beam for preclinical experiments.
    Schwarz, M.
    Saini, J.
    Stappen, F. Vander
    Palmer, L.
    Zeng, J.
    RADIOTHERAPY AND ONCOLOGY, 2023, 182 : S1572 - S1573