Technical note: Commissioning of a linear accelerator producing ultra-high dose rate electrons

被引:5
|
作者
Cetnar, Ashley J. [2 ,3 ]
Jain, Sagarika [1 ]
Gupta, Nilendu [1 ]
Chakravarti, Arnab [1 ]
机构
[1] James Canc Hosp, Dept Radiat Oncol, Columbus, OH USA
[2] James Canc Hosp, Dept Radiat Oncol, 460 W 10th Ave,Suite A201F, Columbus, OH 43210 USA
[3] Ohio State Univ, Solove Res Inst, 460 W 10th Ave,Suite A201F, Columbus, OH 43210 USA
关键词
commissioning; flash; linac; ultra high dose rate; FLASH RADIATION-THERAPY; BEAM DOSIMETRY; IRRADIATION; VALIDATION; SIMULATION;
D O I
10.1002/mp.16925
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Ultra-high dose rate radiation (UHDR) is being explored by researchers in promise of advancing radiation therapy treatments.Purpose: This work presents the commissioning of Varian's Flash Extension for research (FLEX) conversion of a Clinac to deliver UHDR electrons.Methods: A Varian Clinac iX with the FLEX conversion was commissioned for non-clinical research use with 16 MeV UHDR (16H) energy. This involved addition of new hardware, optimizing the electron gun voltages, radiofrequency (RF) power, and steering coils in order to maximize the accelerated electron beam current, sending the beam through custom scattering foils to produce the UHDR with 16H beam. Profiles and percent depth dose (PDD) measurements for 16H were obtained using radiochromic film in a custom vertical film holder and were compared to 16 MeV conventional electrons (16C). Dose rate and dose per pulse (DPP) were calculated from measured dose in film. Linearity and stability were assessed using an Advanced Markus ionization chamber.Results: Energies for 16H and 16C had similar beam quality based on PDD measurements. Measurements at the head of the machine (61.3 cm SSD) with jaws set to 10x10 cm(2) showed the FWHM of the profile as 7.2 cm, with 3.4 Gy as the maximum DPP and instantaneous dose rate of 8.1E5 Gy/s. Measurements at 100 cm SSD with 10 cm standard cone showed the full width at half max (FWHM) of the profile as 10.5 cm, 1.08 Gy as the maximum DPP and instantaneous dose rate of 2.E5 Gy/s. Machine output with number of pulses was linear (R = 1) from 1 to 99 delivered pulses. Output stability was measured within +/- 1% within the same session and within +/- 2% for daily variations.Conclusions: The FLEX conversion of the Clinac is able to generate UHDR electron beams which are reproducible with beam properties similar to clinically used electrons at 16 MeV. Having a platform which can quickly transition between UHDR and conventional modes (<1 min) can be advantageous for future research applications.
引用
收藏
页码:1415 / 1420
页数:6
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