Association between genetically predicted rheumatoid arthritis and alopecia areata: a two-sample Mendelian randomization study

被引:1
|
作者
Zhong, Shengdong [1 ]
Lan, Liting [2 ,3 ]
Zheng, Zicheng [1 ]
Zhang, Huaiyuan [4 ]
Wen, Yuqing [1 ]
机构
[1] Fujian Med Univ, Dept Plast Surg, Longyan Affiliated Hosp 1, Longyan, Peoples R China
[2] Shantou Univ, Clin Res Ctr, Affiliated Hosp 1, Med Coll, Shantou, Guangdong, Peoples R China
[3] Shantou Univ, Clin Res Ctr, Longgang Matern & Child Clin Inst, Med Coll,Med Coll, Shenzhen, Peoples R China
[4] Fudan Univ, Dept Orthoped, Jinshan Hosp, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
rheumatoid arthritis; alopecia areata; autoimmune disease; causation; Mendelian randomization; genetics; CAUSAL INFERENCE; INSTRUMENTS; AUTOIMMUNE; NOTCH4; RISK; GENE; BIAS;
D O I
10.3389/fimmu.2023.1269640
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Although numerous observational studies have indicated a potential association between autoimmune diseases, such as rheumatoid arthritis (RA) and alopecia areata (AA), the research reports lack a clear causal relationship. In this study, our objective is to utilize the Mendelian randomization (MR) design to examine the potential causal association between RA and AA.Methods: To investigate the causal relationship between RA and AA, we utilized large-scale gene aggregation data from genome-wide association studies (GWAS), including RA (n=58,284) and AA (n=361,822) based on previous observational studies. In our analysis, we mainly employed the inverse variance-weighted (IVW) method of the random effects model, supplemented by the weighted median (WM) method and the MR Egger method.Results: The findings from the IVW methods revealed a significant association between genetically predicted RA and an increased likelihood of AA, as evidenced by an odds ratio of 1.21 (95%CI = 1.11-1.32; P < 0.001. Both the WM method and MR-Egger regression consistently showed significant directional outcomes (Both P < 0.05), indicating a robust association between RA and AA. Additionally, both the funnel plot and the MR-Egger intercepts provided evidence of the absence of directional pleiotropy, suggesting that the observed association is not influenced by other common genetic factors.Conclusions: The results of the study suggest a possible link between genetically predicted RA and AA. This finding highlights the importance for individuals diagnosed with RA to remain vigilant and aware of the potential development of AA. Regular monitoring and early detection can be crucial in managing and addressing this potential complication.
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页数:9
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