Association between genetically predicted rheumatoid arthritis and alopecia areata: a two-sample Mendelian randomization study

被引:1
|
作者
Zhong, Shengdong [1 ]
Lan, Liting [2 ,3 ]
Zheng, Zicheng [1 ]
Zhang, Huaiyuan [4 ]
Wen, Yuqing [1 ]
机构
[1] Fujian Med Univ, Dept Plast Surg, Longyan Affiliated Hosp 1, Longyan, Peoples R China
[2] Shantou Univ, Clin Res Ctr, Affiliated Hosp 1, Med Coll, Shantou, Guangdong, Peoples R China
[3] Shantou Univ, Clin Res Ctr, Longgang Matern & Child Clin Inst, Med Coll,Med Coll, Shenzhen, Peoples R China
[4] Fudan Univ, Dept Orthoped, Jinshan Hosp, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
rheumatoid arthritis; alopecia areata; autoimmune disease; causation; Mendelian randomization; genetics; CAUSAL INFERENCE; INSTRUMENTS; AUTOIMMUNE; NOTCH4; RISK; GENE; BIAS;
D O I
10.3389/fimmu.2023.1269640
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Although numerous observational studies have indicated a potential association between autoimmune diseases, such as rheumatoid arthritis (RA) and alopecia areata (AA), the research reports lack a clear causal relationship. In this study, our objective is to utilize the Mendelian randomization (MR) design to examine the potential causal association between RA and AA.Methods: To investigate the causal relationship between RA and AA, we utilized large-scale gene aggregation data from genome-wide association studies (GWAS), including RA (n=58,284) and AA (n=361,822) based on previous observational studies. In our analysis, we mainly employed the inverse variance-weighted (IVW) method of the random effects model, supplemented by the weighted median (WM) method and the MR Egger method.Results: The findings from the IVW methods revealed a significant association between genetically predicted RA and an increased likelihood of AA, as evidenced by an odds ratio of 1.21 (95%CI = 1.11-1.32; P < 0.001. Both the WM method and MR-Egger regression consistently showed significant directional outcomes (Both P < 0.05), indicating a robust association between RA and AA. Additionally, both the funnel plot and the MR-Egger intercepts provided evidence of the absence of directional pleiotropy, suggesting that the observed association is not influenced by other common genetic factors.Conclusions: The results of the study suggest a possible link between genetically predicted RA and AA. This finding highlights the importance for individuals diagnosed with RA to remain vigilant and aware of the potential development of AA. Regular monitoring and early detection can be crucial in managing and addressing this potential complication.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] Genetically predicted testosterone and cancers risk in men: a two-sample Mendelian randomization study
    Junke Chang
    Yongming Wu
    Sicheng Zhou
    Ye Tian
    Yan Wang
    Jie Tian
    Wenpeng Song
    Yinxian Dong
    Jue Li
    Ziyi Zhao
    Guowei Che
    Journal of Translational Medicine, 20
  • [22] Genetically predicted chronic rhinosinusitis and the risk of stroke: a two-sample Mendelian randomization study
    Hu, Jingjing
    Wang, Hui
    Zhou, Yidan
    FRONTIERS IN NEUROLOGY, 2024, 14
  • [23] Bidirectional two-sample Mendelian randomization study of causality between rheumatoid arthritis and myocardial infarction
    Guo, Hao-Yang
    Wang, Wei
    Peng, Hui
    Yuan, Hui
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [24] Associations between rheumatoid arthritis and skin cancer: A bidirectional two-sample Mendelian randomization study
    Yu, Nianzhou
    Qi, Haoxiang
    Guo, Yeye
    Wu, Lisha
    Su, Juan
    Huang, Kai
    Li, Yixin
    Jiang, Zixi
    Zhao, Shuang
    Chen, Xiang
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2023, 90 (01) : 198 - 200
  • [25] Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis
    Zijian Cheng
    Lu Gao
    Peng Huang
    Dingwen Luo
    Chunsheng Bi
    Xiaoyan Chen
    Clinical Oral Investigations, 28
  • [26] Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis
    Cheng, Zijian
    Gao, Lu
    Huang, Peng
    Luo, Dingwen
    Bi, Chunsheng
    Chen, Xiaoyan
    CLINICAL ORAL INVESTIGATIONS, 2024, 28 (01)
  • [27] Association between non-scarring alopecia and hypothyroidism: a bidirectional two-sample Mendelian randomization study
    Yang, Jiankang
    Zhu, Zhenlai
    Zhang, Chen
    Guo, Yanyang
    Wang, Gang
    Fu, Meng
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15
  • [28] Causal association of monounsaturated fatty acids with rheumatoid arthritis but not osteoarthritis: A two-sample Mendelian randomization study
    Sun, Lingling
    Zhu, Jiahao
    Mi, Shuai
    Li, Yasong
    Wang, Tianle
    Li, Yingjun
    NUTRITION, 2021, 91-92
  • [29] Genetically predicted circulating serum homocysteine levels on osteoporosis: a two-sample mendelian randomization study
    Wang, ChenYu
    Zhang, Xiang
    Qiu, Bo
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [30] Genetically predicted frailty index and risk of cutaneous melanoma: a two-sample Mendelian randomization study
    Zhou, Zongpeng
    Cui, Chang
    Yuan, Yi
    Ma, Zhefu
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2024, 317 (01)