Association between genetically predicted rheumatoid arthritis and alopecia areata: a two-sample Mendelian randomization study

被引:1
|
作者
Zhong, Shengdong [1 ]
Lan, Liting [2 ,3 ]
Zheng, Zicheng [1 ]
Zhang, Huaiyuan [4 ]
Wen, Yuqing [1 ]
机构
[1] Fujian Med Univ, Dept Plast Surg, Longyan Affiliated Hosp 1, Longyan, Peoples R China
[2] Shantou Univ, Clin Res Ctr, Affiliated Hosp 1, Med Coll, Shantou, Guangdong, Peoples R China
[3] Shantou Univ, Clin Res Ctr, Longgang Matern & Child Clin Inst, Med Coll,Med Coll, Shenzhen, Peoples R China
[4] Fudan Univ, Dept Orthoped, Jinshan Hosp, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
rheumatoid arthritis; alopecia areata; autoimmune disease; causation; Mendelian randomization; genetics; CAUSAL INFERENCE; INSTRUMENTS; AUTOIMMUNE; NOTCH4; RISK; GENE; BIAS;
D O I
10.3389/fimmu.2023.1269640
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Although numerous observational studies have indicated a potential association between autoimmune diseases, such as rheumatoid arthritis (RA) and alopecia areata (AA), the research reports lack a clear causal relationship. In this study, our objective is to utilize the Mendelian randomization (MR) design to examine the potential causal association between RA and AA.Methods: To investigate the causal relationship between RA and AA, we utilized large-scale gene aggregation data from genome-wide association studies (GWAS), including RA (n=58,284) and AA (n=361,822) based on previous observational studies. In our analysis, we mainly employed the inverse variance-weighted (IVW) method of the random effects model, supplemented by the weighted median (WM) method and the MR Egger method.Results: The findings from the IVW methods revealed a significant association between genetically predicted RA and an increased likelihood of AA, as evidenced by an odds ratio of 1.21 (95%CI = 1.11-1.32; P < 0.001. Both the WM method and MR-Egger regression consistently showed significant directional outcomes (Both P < 0.05), indicating a robust association between RA and AA. Additionally, both the funnel plot and the MR-Egger intercepts provided evidence of the absence of directional pleiotropy, suggesting that the observed association is not influenced by other common genetic factors.Conclusions: The results of the study suggest a possible link between genetically predicted RA and AA. This finding highlights the importance for individuals diagnosed with RA to remain vigilant and aware of the potential development of AA. Regular monitoring and early detection can be crucial in managing and addressing this potential complication.
引用
收藏
页数:9
相关论文
共 50 条
  • [31] Causal Effects of Genetically Predicted Cystatin C on Osteoporosis: A Two-Sample Mendelian Randomization Study
    Yuan, Jiaqin
    Peng, Lipeng
    Luan, Fujun
    Li, Jie
    Zhang, Jinglin
    Jiang, Wei
    Wang, Wenting
    FRONTIERS IN GENETICS, 2022, 13
  • [32] Genetically predicted circulating serum homocysteine levels on osteoporosis: a two-sample mendelian randomization study
    ChenYu Wang
    Xiang Zhang
    Bo Qiu
    Scientific Reports, 13
  • [33] Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study
    Yan, Shuixin
    Li, Jiadi
    Chen, Jiafeng
    Chen, Yan
    Qiu, Yu
    Zhou, Yuxin
    Wu, Weizhu
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [34] Genetically Predicted Atrial Fibrillation and Valvular Heart Disease: A Two-Sample Mendelian Randomization Study
    Gao, Jie
    Bai, Yulin
    Ji, Hongwen
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [35] Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study
    Shuixin Yan
    Jiadi Li
    Jiafeng Chen
    Yan Chen
    Yu Qiu
    Yuxin Zhou
    Weizhu Wu
    Scientific Reports, 13
  • [36] Causal relationship between rheumatoid arthritis and ankylosing spondylitis: Two-sample Mendelian randomization
    Deng, Guang-hua
    MEDICINE, 2024, 103 (30)
  • [37] Association between leptin and NAFLD: a two-sample Mendelian randomization study
    Guo, Ziwei
    Du, Hongbo
    Guo, Yi
    Jin, Qian
    Liu, Ruijia
    Yun, Zhangjun
    Zhang, Jiaxin
    Li, Xiaoke
    Ye, Yong'an
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2023, 28 (01)
  • [38] Association between leptin and NAFLD: a two-sample Mendelian randomization study
    Ziwei Guo
    Hongbo Du
    Yi Guo
    Qian Jin
    Ruijia Liu
    Zhangjun Yun
    Jiaxin Zhang
    Xiaoke Li
    Yong’an Ye
    European Journal of Medical Research, 28
  • [39] Assessment of Bidirectional Relationships between Mental Illness and Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study
    Xiang, Shate
    Wang, Rongyun
    Hua, Lijiangshan
    Song, Jie
    Qian, Suhai
    Jin, Yibo
    Zhang, Bingyue
    Ding, Xinghong
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (03)
  • [40] Comment on "Associations between rheumatoid arthritis and skin cancer: A bidirectional two-sample Mendelian randomization study"
    Wang, Zhe
    Li, Da
    Qi, Bingran
    Zhang, Cheng
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2024, 91 (03) : e85 - e85