A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA

被引：0

作者：

Wu, Furong ^{[1
]}

Zhang, Wenxiu ^{[2
]}

Bo, Xianglong ^{[1
]}

Feng, Qin ^{[1
]}

Tan, Meijing ^{[1
]}

Ju, Shichao ^{[1
]}

Song, Zishuo ^{[1
]}

Li, Jun ^{[1
]}

Huang, Xishan ^{[1
]}

机构：

[1] Guangxi Normal Univ, Coll Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China

[2] Hechi Univ, Sch Chem & Bioengn, Yizhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年

基金：

中国国家自然科学基金;

关键词：

Aspergillus sp; endophytic fungus; asperiguxidione A; antibacterial; anti-inflammatory;

D O I：

10.1080/14786419.2023.2288685

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new sulphur-containing metabolite, asperiguxidione A (1), was isolated from a mangrove endophytic fungus Aspergillus sp. GXNU-MA, and four known alkaloids 2-5, were isolated together from this strain. Their structures were determined by the com-bination of 1D and 2D NMR spectroscopy, HR-ESI-MS, and ECD analysis. Compounds 1 and 2 exhibited mediate activity against Staphylococcus aureus and Enterobacter aerogenes with equal MIC values of 12.5 mu g/mL. Compound 3 reduced NO production in LPS-stimulated cells with an IC50 value of 13.329 +/- 0.53 mu g/mL in the anti-inflammatory assay. [GRAPPHICS].

引用

页数：6

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