Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y85

被引：2

作者：

Qin, Feng ^{[1
,2
]}

Song, Zi-Shuo ^{[1
]}

Luo, Li ^{[1
]}

Bo, Xiang-Long ^{[1
]}

Wu, Fu-Rong ^{[1
]}

Tan, Mei-Jing ^{[1
]}

Wang, Fan-Fan ^{[2
]}

Huang, Xi-Shan ^{[1
]}

Wang, Heng-Shan ^{[1
]}

机构：

[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources, Minist Educ China,Collaborat Innovat Ctr Guangxi E, Guilin 541004, Peoples R China

[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China

来源：

MARINE DRUGS | 2024年 / 22卷 / 02期

基金：

中国国家自然科学基金;

关键词：

mangrove endophytic fungus; Aspergillus sp; meroterpenoids; anti-cancer activity;

D O I：

10.3390/md22020058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N (1-5), along with three known analogues (6-8), were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound 8 had strong cytotoxicity against HeLa cancer cells, and its IC50 value was 11.8 mu M. In addition, flow cytometry analysis revealed that the cytotoxicity of 8 was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.

引用

页数：10

共 50 条

[1] New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain Aspergillus sp. GXNU-Y85
Wang, Chungu
Wang, Fanfan
Tao, Pingfang
Shao, Yuanling
Li, Qing
Gu, Minmin
Liao, Zhixin
Qin, Feng
MARINE DRUGS, 2024, 22 (06)
[2] Diisoprenyl-cyclohexene-type meroterpenoids from a mangrove endophytic fungus Aspergillus sp. GXNU-Y65 and their anti-nonalcoholic steatohepatitis activity in AML12 cells
Qin, Feng
Luo, Li
Liu, Yu-Chen
Bo, Xiang-Long
Wu, Fu-Rong
Wang, Fan-Fan
Tan, Mei-Jing
Wei, You-Quan
Dou, Xiao-Bing
Wang, Cai Yi
Huang, Xi-Shan
Wang, Heng-Shan
PHYTOCHEMISTRY, 2024, 218
[3] Cytotoxic metabolites from the mangrove endophytic fungus Aspergillus sp. GXNU QG1a
Bo, Xianglong
Zhao, Yufei
Qin, Feng
Wu, Furong
Tan, Meijing
Ju, Shichao
Song, Zishuo
Li, Wenjun
He, Fan
Wei, Youquan
Xu, Hua
Huang, Xishan
NATURAL PRODUCT RESEARCH, 2024,
[4] A new lactone from mangrove endophytic fungus Aspergillus sp. GXNU-A9
Zhang, Wenxiu
Hao, Lili
Qin, Xiaoya
Huang, Jiguo
Yang, Ruiyun
Li, Jun
Huang, Xishan
NATURAL PRODUCT RESEARCH, 2023, 37 (03) : 417 - 423
[5] A new isoprenyl-phenol-type meroterpenoid from mangrove endophytic fungus Aspergillus sp. GXNU-Y65
Wang, Fan-Fan
Huang, Guo-Bao
Lu, Cai-Hong
Chen, Li-Jun
Chen, Hui-Zhen
Luo, Meng-Qin
Tao, Ping-Fang
Tan, Ming-Xiong
Qin, Feng
NATURAL PRODUCT RESEARCH, 2024,
[6] A new insecticidal sesquiterpene from a mangrove endophytic fungus Aspergillus strain sp. GXNU R1
Yu, Xiongtao
Tan, Meijing
Bo, Xianglong
Lin, Zhifan
Chen, Jinwei
Huang, Xishan
Huang, Jiguo
NATURAL PRODUCT RESEARCH, 2025,
[7] A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA
Wu, Furong
Zhang, Wenxiu
Bo, Xianglong
Feng, Qin
Tan, Meijing
Ju, Shichao
Song, Zishuo
Li, Jun
Huang, Xishan
NATURAL PRODUCT RESEARCH, 2023,
[8] A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus Aspergillus sp. GXNU-DY2-12
Tan, Meijing
Ju, Shichao
He, Fan
Li, Wenjun
Wei, Youquan
Xu, Weifeng
Yang, Ruiyun
Huang, Xishan
NATURAL PRODUCT RESEARCH, 2025,
[9] Bioactive α-pyrone meroterpenoids from mangrove endophytic fungus Penicillium sp.
Ding, Bo
Wang, Zhiyuan
Huang, Xishan
Liu, Yayue
Chen, Wenrui
She, Zhigang
NATURAL PRODUCT RESEARCH, 2016, 30 (24) : 2805 - 2812
[10] Two new polyketone derivatives from the mangrove endophytic fungus Aspergillus sp. GXNU TH4b
Ju, Shichao
Bo, Xianglong
Wu, Furong
Tan, Meijing
Song, Zisuo
He, Fan
Li, Wenjun
Wei, Youquan
Xu, Weifeng
Yang, Ruiyun
Huang, Xishan
NATURAL PRODUCT RESEARCH, 2024,

← 1 2 3 4 5 →