Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y85

被引：2
|
作者：
Qin, Feng [1 ,2 ]
Song, Zi-Shuo [1 ]
Luo, Li [1 ]
Bo, Xiang-Long [1 ]
Wu, Fu-Rong [1 ]
Tan, Mei-Jing [1 ]
Wang, Fan-Fan [2 ]
Huang, Xi-Shan [1 ]
Wang, Heng-Shan [1 ]
机构：
[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources, Minist Educ China,Collaborat Innovat Ctr Guangxi E, Guilin 541004, Peoples R China
[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China
来源：
MARINE DRUGS | 2024年 / 22卷 / 02期
基金：
中国国家自然科学基金;
关键词：
mangrove endophytic fungus; Aspergillus sp; meroterpenoids; anti-cancer activity;
D O I：
10.3390/md22020058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N (1-5), along with three known analogues (6-8), were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound 8 had strong cytotoxicity against HeLa cancer cells, and its IC50 value was 11.8 mu M. In addition, flow cytometry analysis revealed that the cytotoxicity of 8 was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.
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页数：10
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