Polyketides with anti-inflammatory activity from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7

被引：4
|
作者：
Tang, Xiaoyuan [1 ]
Zhao, Yuxuan [1 ]
Wang, Xude [2 ]
Ye, Chongtao [2 ]
Feng, Baomin [1 ]
Tang, Chuan [1 ]
Lu, Xuan [1 ]
机构：
[1] Dalian Univ, Coll Life Hlth, Dalian 116622, Peoples R China
[2] Dalian Univ, Coll Med, Dalian 116622, Peoples R China
来源：
PHYTOCHEMISTRY | 2022年 / 203卷
关键词：
Rhodiola tibetica; Crassulaceae; Alternaria sp; HJT-Y7; Pleosporaceae; Polyketide; Anti-inflammatory; Endophyte; METABOLITE; NMR;
D O I：
10.1016/j.phytochem.2022.113383
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven undescribed polyketides with particular ortho-trisubstituted benzo[c]furan and benzo[c]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Polyketides with anti-inflammatory activity isolated from Rhodiola tibetica endophytic fungus Penicillium sp. HJT-A-10
    Lu, Xuan
    Qi, Jun-kai
    Tang, Xiao-yuan
    Wang, Xu-de
    Ye, Chong-tao
    Bai, Jing
    Tang, Chuan
    Xi, Yu-fei
    Wu, Bin
    Wan, Xue
    Feng, Bao-min
    FITOTERAPIA, 2023, 164
  • [2] Polyketone metabolites isolated from Rhodiola tibetica endohytic fungus Alternaria sp. HJT-Y7 and their SARS-CoV-2 virus inhibitory activitives
    Lu, Xuan
    Tang, Xiao-Yuan
    Wang, Hai-Xin
    Huang, Wei-jin
    Feng, Wei-Xing
    Feng, Bao-Min
    BIOORGANIC CHEMISTRY, 2021, 116
  • [3] New Polyketides from Mangrove Endophytic Fungus Penicillium sp. BJR-P2 and Their Anti-Inflammatory Activity
    Chen, Chen
    Ye, Geting
    Tang, Jing
    Li, Jialin
    Liu, Wenbin
    Wu, Li
    Long, Yuhua
    MARINE DRUGS, 2022, 20 (09)
  • [4] A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6
    Xiao, Dongliang
    Wang, Yan
    Gao, Congcong
    Zhang, Xuemei
    Feng, Weixing
    Lu, Xuan
    Feng, Baomin
    MOLECULES, 2024, 29 (09):
  • [5] Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09
    Ouyang, Xin
    Chen, Senhua
    Chen, Qiling
    Guo, Heng
    Liu, Lan
    Liu, Hongju
    Yan, Chong
    MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY, 2024,
  • [6] Anti-inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN-EF006 of Vaccinium bracteatum
    Wang, Yin-Yin
    Pan, Yin-Bo
    Wan, Ze-Yi
    Li, Jun-Jiang
    Bao, Jie
    Zhang, Jun-Sheng
    Zhang, Hua
    CHEMISTRY & BIODIVERSITY, 2024, 21 (04)
  • [7] Cytochalasins and polyketides from the fungus Diaporthe sp. GZU-1021 and their anti-inflammatory activity
    Liu, Yena
    Ruan, Qingfeng
    Jiang, Shiqin
    Qu, Yong
    Chen, Jiayan
    Zhao, Min
    Yang, Bao
    Liu, Yingxiang
    Zhao, Zhongxiang
    Cui, Hui
    FITOTERAPIA, 2019, 137
  • [8] Quinones from endophytic fungus Fusarium sp. HJT-P-5 of Rhodiola angusta Nakai
    Lu, Xuan
    Li, Yanjun
    Qin, Haihong
    Tang, Chuan
    Zhang, Yu
    Tang, Xiaoyuan
    Wei, Lei
    Feng, Baomin
    PHYTOCHEMISTRY LETTERS, 2020, 39 : 162 - 167
  • [9] Terpenoids from the endophytic fungus Microdiplodia sp. and their anti-inflammatory activities
    Bi, Yufang
    Yu, Yihu
    Yao, Houzong
    Yuan, Tao
    FITOTERAPIA, 2023, 171
  • [10] Terpenoid derivatives from the endophytic fungus Fusarium sp. HJT-P-2 of Rhodiola angusta Nakai
    Lu, Xuan
    Sun, Yeqing
    Li, Yanjun
    Zhang, Xuemei
    Zhao, Yuxuan
    Feng, Baomin
    PHYTOCHEMISTRY LETTERS, 2021, 45 : 48 - 51
12345