Polyketides with anti-inflammatory activity isolated from Rhodiola tibetica endophytic fungus Penicillium sp. HJT-A-10

被引：3

作者：

Lu, Xuan ^{[1
]}

Qi, Jun-kai ^{[1
]}

Tang, Xiao-yuan ^{[1
]}

Wang, Xu-de ^{[2
]}

Ye, Chong-tao ^{[2
]}

Bai, Jing ^{[3
]}

Tang, Chuan ^{[1
]}

Xi, Yu-fei ^{[1
]}

Wu, Bin ^{[4
]}

Wan, Xue ^{[4
]}

Feng, Bao-min ^{[1
]}

机构：

[1] Dalian Univ, Coll Life & Hlth, Dalian 116622, Peoples R China

[2] Dalian Univ, Med Coll, Dalian 116622, Peoples R China

[3] Suzhou Univ Sci & Technol, Sch Chem & Life Sci, Suzhou 215009, Peoples R China

[4] China Certificat & Inspection Grp Liaoning Co Ltd, Dalian 116622, Peoples R China

来源：

FITOTERAPIA | 2023年 / 164卷

关键词：

Penicillium sp; Polyketides; Tanzawaic acid; Anti-inflammatory activity; MARINE-DERIVED FUNGUS; DIELS-ALDER REACTION; BIOSYNTHESIS; ACIDS;

D O I：

10.1016/j.fitote.2022.105361

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven undescribed polyketide compounds (1-4, 9-11) and six known polyketide compounds (5-8,12, 13) were isolated from Rhodiola tibetica endophytic Penicillium sp. HJT-A-10. The structural of seven undescribed poly-ketides metabolites were established on the basis of spectroscopic methods. The results of anti-inflammatory activity showed that compounds 1-8,10-13 had significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells.

引用

页数：9

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