A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA

被引：0
|
作者：
Wu, Furong [1 ]
Zhang, Wenxiu [2 ]
Bo, Xianglong [1 ]
Feng, Qin [1 ]
Tan, Meijing [1 ]
Ju, Shichao [1 ]
Song, Zishuo [1 ]
Li, Jun [1 ]
Huang, Xishan [1 ]
机构：
[1] Guangxi Normal Univ, Coll Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China
[2] Hechi Univ, Sch Chem & Bioengn, Yizhou, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年
基金：
中国国家自然科学基金;
关键词：
Aspergillus sp; endophytic fungus; asperiguxidione A; antibacterial; anti-inflammatory;
D O I：
10.1080/14786419.2023.2288685
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new sulphur-containing metabolite, asperiguxidione A (1), was isolated from a mangrove endophytic fungus Aspergillus sp. GXNU-MA, and four known alkaloids 2-5, were isolated together from this strain. Their structures were determined by the com-bination of 1D and 2D NMR spectroscopy, HR-ESI-MS, and ECD analysis. Compounds 1 and 2 exhibited mediate activity against Staphylococcus aureus and Enterobacter aerogenes with equal MIC values of 12.5 mu g/mL. Compound 3 reduced NO production in LPS-stimulated cells with an IC50 value of 13.329 +/- 0.53 mu g/mL in the anti-inflammatory assay. [GRAPPHICS].
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页数：6
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