A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA

被引：0
|
作者：
Wu, Furong [1 ]
Zhang, Wenxiu [2 ]
Bo, Xianglong [1 ]
Feng, Qin [1 ]
Tan, Meijing [1 ]
Ju, Shichao [1 ]
Song, Zishuo [1 ]
Li, Jun [1 ]
Huang, Xishan [1 ]
机构：
[1] Guangxi Normal Univ, Coll Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China
[2] Hechi Univ, Sch Chem & Bioengn, Yizhou, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年
基金：
中国国家自然科学基金;
关键词：
Aspergillus sp; endophytic fungus; asperiguxidione A; antibacterial; anti-inflammatory;
D O I：
10.1080/14786419.2023.2288685
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new sulphur-containing metabolite, asperiguxidione A (1), was isolated from a mangrove endophytic fungus Aspergillus sp. GXNU-MA, and four known alkaloids 2-5, were isolated together from this strain. Their structures were determined by the com-bination of 1D and 2D NMR spectroscopy, HR-ESI-MS, and ECD analysis. Compounds 1 and 2 exhibited mediate activity against Staphylococcus aureus and Enterobacter aerogenes with equal MIC values of 12.5 mu g/mL. Compound 3 reduced NO production in LPS-stimulated cells with an IC50 value of 13.329 +/- 0.53 mu g/mL in the anti-inflammatory assay. [GRAPPHICS].
引用
收藏
页数：6
相关论文
共 50 条
  • [31] A new sesquiterpene from mangrove endophytic fungusAspergillussp. GXNU-MA1
    Zhou, Dexiong
    Zhang, Wenxiu
    Hao, Lili
    Qin, Xiaoya
    Yang, Ruiyun
    Li, Jun
    Huang, Xishan
    NATURAL PRODUCT RESEARCH, 2022, 36 (07) : 1857 - 1863
  • [32] New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242
    GUO Hui-Xian
    HUANG Cui-Ying
    YAN Zhang-Yuan
    CHEN Tao
    HONG Kui
    LONG Yu-Hua
    Chinese Journal of Natural Medicines, 2020, 18 (11) : 855 - 859
  • [33] New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242
    Guo Hui-Xian
    Huang Cui-Ying
    Yan Zhang-Yuan
    Chen Tao
    Hong Kui
    Long Yu-Hua
    CHINESE JOURNAL OF NATURAL MEDICINES, 2020, 18 (11) : 855 - 859
  • [34] New immunosuppressive secondary metabolites from the endophytic fungus Aspergillus sp.
    Deng, Mengyi
    Chen, Xia
    Shi, Zhengyi
    Xie, Shuangshuang
    Qiao, Yuben
    Chen, Gang
    Tan, Xiaosheng
    Lu, Yuanyuan
    Qi, Changxing
    Zhang, Yonghui
    FITOTERAPIA, 2021, 151
  • [35] Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
    Wang, Jinhua
    Cox, Daniel G.
    Ding, Weijia
    Huang, Guanghao
    Lin, Yongcheng
    Li, Chunyuan
    MARINE DRUGS, 2014, 12 (05): : 2840 - 2850
  • [36] A new terrein dimer and a new meroterpene from the mangrove endophytic fungus Lichtheimia sp.
    Ren, Jing-Ling
    Li, Cai-Mao
    Shen, Li
    Wu, Jun
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023, 25 (11) : 1068 - 1075
  • [37] Chemical constituents from the mangrove endophytic fungus Sporothrix sp.
    Wen, Lu
    Wei, Qiqiu
    Chen, Gang
    Cai, Juanni
    She, Zhigang
    CHEMISTRY OF NATURAL COMPOUNDS, 2013, 49 (01) : 137 - 140
  • [38] Chemical constituents from the mangrove endophytic fungus Sporothrix sp.
    Lu Wen
    Qiqiu Wei
    Gang Chen
    Juanni Cai
    Zhigang She
    Chemistry of Natural Compounds, 2013, 49 : 137 - 140
  • [39] A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus Penicillium sp.
    Li, Jing
    Zhong, Yi-sheng
    Yuan, Jie
    Zhu, Xun
    Lu, Yong-jun
    Lin, Yong-cheng
    Liu, Lan
    NATURAL PRODUCT COMMUNICATIONS, 2015, 10 (09) : 1549 - 1551
  • [40] Ophiobolin-Type Sesterterpenoids from the Mangrove Endophytic Fungus Aspergillus sp. ZJ-68
    Cai, Runlin
    Jiang, Hongming
    Mo, Yaling
    Guo, Huixian
    Li, Chunyuan
    Long, Yuhua
    Zang, Zhenming
    She, Zhigang
    JOURNAL OF NATURAL PRODUCTS, 2019, 82 (08): : 2268 - 2278
12345