Polygenic Risk Scores for Bipolar Disorder: Progress and

被引：3
|
作者：
Liu, Huanxi [1 ,2 ]
Wang, Ligang [2 ]
Yu, Hui [2 ]
Chen, Jun [3 ]
Sun, Ping [2 ,4 ]
机构：
[1] Qingdao Univ, Qingdao Med Coll, Qingdao 266071, Peoples R China
[2] Qingdao Mental Hlth Ctr, Qingdao 266034, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Clin Res Ctr, Shanghai, Peoples R China
[4] Mental Hlth Ctr, Qingdao 266034, Peoples R China
来源：
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2023年 / 19卷
关键词：
bipolar disorder; polygenic risk scores; risk forecast; SCHIZOPHRENIA;
D O I：
10.2147/NDT.S433023
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genomewide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases. This review discusses phenotypic associations and genetic correlations with other conditions of BD based on PRS, and provides ideas for genetic studies and prevention of BD.
引用
收藏
页码：2617 / 2626
页数：10
相关论文
共 50 条
  • [41] Polygenic Risk Scores for Bipolar Disorders Associated With Worse Global Functioning
    Diaz, Alexandre Paim
    Fries, Gabriel
    Quevedo, Joao
    Walss-Bass, Consuelo
    Sanches, Marsal
    Soares, Jair
    BIOLOGICAL PSYCHIATRY, 2020, 87 (09) : S211 - S211
  • [42] HIGH POLYGENIC RISK SCORES ASSOCIATED WITH AUTISM SPECTRUM DISORDER
    Nelson, Roxanne
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2020, 182 (05) : 949 - +
  • [43] Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence
    Andersen, Allan M.
    Pietrzak, Robert H.
    Kranzler, Henry R.
    Ma, Li
    Zhou, Hang
    Liu, Xiaoming
    Kramer, John
    Kuperman, Samuel
    Edenberg, Howard J.
    Nurnberger, John I., Jr.
    Rice, John P.
    Tischfield, Jay A.
    Goate, Alison
    Foroud, Tatiana M.
    Meyers, Jacquelyn L.
    Porjesz, Bernice
    Dick, Danielle M.
    Hesselbrock, Victor
    Boerwinkle, Eric
    Southwick, Steven M.
    Krystal, John H.
    Weissman, Myrna M.
    Levinson, Douglas F.
    Potash, James B.
    Gelernter, Joel
    Han, Shizhong
    JAMA PSYCHIATRY, 2017, 74 (11) : 1153 - 1160
  • [44] Polygenic risk scores
    Watson, Roger
    JOURNAL OF ADVANCED NURSING, 2019, 75 (08) : 1606 - 1607
  • [45] Polygenic risk scores
    Brown, Matthew A.
    SEMINARS IN ARTHRITIS AND RHEUMATISM, 2024, 64
  • [46] Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    Nature, 2009, 460 : 748 - 752
  • [47] Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    Purcell, Shaun M.
    Wray, Naomi R.
    Stone, Jennifer L.
    Visscher, Peter M.
    O'Donovan, Michael C.
    Sullivan, Patrick F.
    Sklar, Pamela
    Ruderfer, Douglas M.
    McQuillin, Andrew
    Morris, Derek W.
    O'Dushlaine, Colm T.
    Corvin, Aiden
    Holmans, Peter A.
    Macgregor, Stuart
    Gurling, Hugh
    Blackwood, Douglas H. R.
    Craddock, Nick J.
    Gill, Michael
    Hultman, Christina M.
    Kirov, George K.
    Lichtenstein, Paul
    Muir, Walter J.
    Owen, Michael J.
    Pato, Carlos N.
    Scolnick, Edward M.
    St Clair, David
    Williams, Nigel M.
    Georgieva, Lyudmila
    Nikolov, Ivan
    Norton, N.
    Williams, H.
    Toncheva, Draga
    Milanova, Vihra
    Thelander, Emma F.
    Sullivan, Patrick
    Kenny, Elaine
    Quinn, Emma M.
    Choudhury, Khalid
    Datta, Susmita
    Pimm, Jonathan
    Thirumalai, Srinivasa
    Puri, Vinay
    Krasucki, Robert
    Lawrence, Jacob
    Quested, Digby
    Bass, Nicholas
    Crombie, Caroline
    Fraser, Gillian
    Kuan, Soh Leh
    Walker, Nicholas
    NATURE, 2009, 460 (7256) : 748 - 752
  • [48] Polygenic Risk and Episode Polarity Among Individuals With Bipolar Disorder
    Hasseris, Sofie
    Albinana, Clara
    Vilhjalmsson, Bjarni J.
    Mortensen, Preben B.
    ostergaard, Soren D.
    Musliner, Katherine L.
    AMERICAN JOURNAL OF PSYCHIATRY, 2023, 180 (03): : 200 - 208
  • [49] POLYGENIC RISK SCORES ANALYSIS OF ALCOHOL USE DISORDER: RISK EVALUATIONS AND BEYOND
    Hart, R. P.
    Popova, D.
    Zalamea, P.
    Jadali, A.
    Gao, H.
    Kwan, K.
    Pang, Z. P.
    Slesinger, P.
    Liu, Y.
    Edenberg, H. J.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2022, 46 : 15A - 15A
  • [50] Polygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkers
    Reponen, Elina J.
    Ueland, Thor
    Rokicki, Jaroslav
    Bettella, Francesco
    Aas, Monica
    Werner, Maren C. F.
    Dieset, Ingrid
    Steen, Nils E.
    Andreassen, Ole A.
    Tesli, Martin
    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2024, 274 (05) : 1223 - 1230
12345