Polygenic Risk Scores for Bipolar Disorder: Progress and

被引：3
|
作者：
Liu, Huanxi [1 ,2 ]
Wang, Ligang [2 ]
Yu, Hui [2 ]
Chen, Jun [3 ]
Sun, Ping [2 ,4 ]
机构：
[1] Qingdao Univ, Qingdao Med Coll, Qingdao 266071, Peoples R China
[2] Qingdao Mental Hlth Ctr, Qingdao 266034, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Clin Res Ctr, Shanghai, Peoples R China
[4] Mental Hlth Ctr, Qingdao 266034, Peoples R China
来源：
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2023年 / 19卷
关键词：
bipolar disorder; polygenic risk scores; risk forecast; SCHIZOPHRENIA;
D O I：
10.2147/NDT.S433023
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genomewide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases. This review discusses phenotypic associations and genetic correlations with other conditions of BD based on PRS, and provides ideas for genetic studies and prevention of BD.
引用
收藏
页码：2617 / 2626
页数：10
相关论文
共 50 条
  • [1] Polygenic risk scores in bipolar disorder subgroups
    Aminoff, Sofie Ragnhild
    Tesli, Martin
    Bettella, Francesco
    Aas, Monica
    Lagerberg, Trine Vik
    Djurovic, Srdjan
    Andreassen, Ole A.
    Melle, Ingrid
    JOURNAL OF AFFECTIVE DISORDERS, 2015, 183 : 310 - 314
  • [2] Transdiagnostic Polygenic Risk Scores in Youth With Bipolar Disorder
    Jiang, Xinyue
    Zai, Clement C.
    Kennedy, James
    Birmaher, Boris
    Goldstein, Benjamin
    BIOLOGICAL PSYCHIATRY, 2023, 93 (09) : S66 - S66
  • [3] Mismatch negativity and polygenic risk scores for schizophrenia and bipolar disorder
    Pentz, Atle Brathen
    O'Connel, Kevin Sean
    van Jole, Oda
    Timpe, Clara Maria Fides
    Slapo, Nora Berz
    Melle, Ingrid
    Lagerberg, Trine Vik
    Steen, Nils Eiel
    Westlye, Lars T.
    Haukvik, Unn K.
    Moberget, Torgeir
    Jonsson, Erik G.
    Andreassen, Ole A.
    Elvsashagen, Torbjorn
    SCHIZOPHRENIA RESEARCH, 2024, 264 : 314 - 326
  • [4] Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
    Power, Robert A.
    Steinberg, Stacy
    Bjornsdottir, Gyda
    Rietveld, Cornelius A.
    Abdellaoui, Abdel
    Nivard, Michel M.
    Johannesson, Magnus
    Galesloot, Tessel E.
    Hottenga, Jouke J.
    Willemsen, Gonneke
    Cesarini, David
    Benjamin, Daniel J.
    Magnusson, Patrik K. E.
    Ullen, Fredrik
    Tiemeier, Henning
    Hofman, Albert
    Van Rooij, Frank J. A.
    Walters, G. Bragi
    Sigurdsson, Engilbert
    Thorgeirsson, Thorgeir E.
    Ingason, Andres
    Helgason, Agnar
    Kong, Augustine
    Kiemeney, Lambertus A.
    Koellinger, Philipp
    Boomsma, Dorret I.
    Gudbjartsson, Daniel
    Stefansson, Hreinn
    Stefansson, Kari
    NATURE NEUROSCIENCE, 2015, 18 (07) : 953 - +
  • [5] Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
    Robert A Power
    Stacy Steinberg
    Gyda Bjornsdottir
    Cornelius A Rietveld
    Abdel Abdellaoui
    Michel M Nivard
    Magnus Johannesson
    Tessel E Galesloot
    Jouke J Hottenga
    Gonneke Willemsen
    David Cesarini
    Daniel J Benjamin
    Patrik K E Magnusson
    Fredrik Ullén
    Henning Tiemeier
    Albert Hofman
    Frank J A van Rooij
    G Bragi Walters
    Engilbert Sigurdsson
    Thorgeir E Thorgeirsson
    Andres Ingason
    Agnar Helgason
    Augustine Kong
    Lambertus A Kiemeney
    Philipp Koellinger
    Dorret I Boomsma
    Daniel Gudbjartsson
    Hreinn Stefansson
    Kari Stefansson
    Nature Neuroscience, 2015, 18 : 953 - 955
  • [6] Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
    Reginsson, Gunnar W.
    Ingason, Andres
    Euesden, Jack
    Bjornsdottir, Gyda
    Olafsson, Sigurgeir
    Sigurdsson, Engilbert
    Oskarsson, Hogni
    Tyrfingsson, Thorarinn
    Runarsdottir, Valgerdur
    Hansdottir, Ingunn
    Steinberg, Stacy
    Stefansson, Hreinn
    Gudbjartsson, Daniel F.
    Thorgeirsson, Thorgeir E.
    Stefansson, Kari
    ADDICTION BIOLOGY, 2018, 23 (01) : 485 - 492
  • [7] Exploration of experiences with and understanding of polygenic risk scores for bipolar disorder
    Putt, Sophie
    Yanes, Tatiane
    Meiser, Bettina
    Kaur, Rajneesh
    Fullerton, Janice M.
    Barlow-Stewart, Kristine
    Schofield, Peter R.
    Toma, Claudio
    Peay, Holly
    Mitchell, Philip B.
    JOURNAL OF AFFECTIVE DISORDERS, 2020, 265 : 342 - 350
  • [8] EFFECTS OF SCHIZOPHRENIA AND BIPOLAR POLYGENIC RISK SCORES ON AGE AT ONSET IN BIPOLAR DISORDER
    Kalman, Janos
    Papiol, Sergi
    Heilbronner, Urs
    Andlauer, Till F. M.
    Anderson-Schmidt, Heike
    Budde, Monika
    Gade, Katrin
    Herms, Stefan
    Forstner, Andreas J.
    Frank, Josef
    Degenhardt, Franziska
    Noethen, Markus
    Rietschel, Marcella
    Falkai, Peter
    Schulze, Thomas
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S967 - S967
  • [9] THE IMPACT OF BIPOLAR AND SCHIZOPHRENIA POLYGENIC RISK SCORES ON FAMILIAL FEATURES OF BIPOLAR DISORDER
    Gade, Katrin
    Papiol, Sergi
    Heilbronner, Urs
    Budde, Monika
    Adorjan, Kristina
    Anderson-Schmidt, Heike
    Kalman, Janos
    Aldinger, Fanny
    Andlauer, Till F. M.
    Schulze, Thomas
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S968 - S968
  • [10] Neurostructural Phenotypes Associated With Bipolar Disorder Polygenic Risk Scores in Youth
    Jiang, Xinyue
    Zai, Clement C.
    Kennedy, Kody G.
    Nikolova, Yuliya
    Felsky, Daniel
    Goldstein, Benjamin I.
    BIOLOGICAL PSYCHIATRY, 2023, 93 (09) : S168 - S168
12345