Polygenic Risk Scores for Bipolar Disorder: Progress and

被引：3

作者：

Liu, Huanxi ^{[1
,2
]}

Wang, Ligang ^{[2
]}

Yu, Hui ^{[2
]}

Chen, Jun ^{[3
]}

Sun, Ping ^{[2
,4
]}

机构：

[1] Qingdao Univ, Qingdao Med Coll, Qingdao 266071, Peoples R China

[2] Qingdao Mental Hlth Ctr, Qingdao 266034, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Clin Res Ctr, Shanghai, Peoples R China

[4] Mental Hlth Ctr, Qingdao 266034, Peoples R China

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2023年 / 19卷

关键词：

bipolar disorder; polygenic risk scores; risk forecast; SCHIZOPHRENIA;

D O I：

10.2147/NDT.S433023

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention and individualized treatment. At the same time, BD is a highly heterogeneous polygenic genetic disorder with significant genetic overlap with other psychiatric disorders. In recent years, polygenic risk scores (PRS) derived from genomewide association studies (GWAS) data have been widely used in genetic studies of various complex diseases and can be used to explore the genetic susceptibility of diseases. This review discusses phenotypic associations and genetic correlations with other conditions of BD based on PRS, and provides ideas for genetic studies and prevention of BD.

引用

页码：2617 / 2626

页数：10

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