Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity

被引：1
|
作者：
Zhurakulov, Sh. N. [1 ,2 ]
Narbutaeva, D. A. [1 ]
Karakulova, A. M. [1 ]
Tursunkhodzhaeva, F. M. [1 ]
Vinogradova, V. I. [1 ]
机构：
[1] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, 77 Mirzo Ulugbek St, Tashkent 100170, Uzbekistan
[2] Mirzo Ulugbek Natl Univ Uzbekistan, 4 Univ Skaya St, Tashkent 100174, Uzbekistan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 04期
关键词：
quercetin; 1-aryltetrahydroisoquinolines; aminomethylation reaction; hypoxia; DIHYDROQUERCETIN; FLAVONOIDS;
D O I：
10.1007/s10600-023-04080-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Monosubstituted quercetin conjugates were synthesized via Mannich reactions from 1-aryl-(or H)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines in 75-96% yields. Compounds with antihypoxic activity more effective than that of quercetin were found among them.
引用
收藏
页码：655 / 661
页数：7
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