Synthesis and Biological Evaluation of Novel Tetrahydroisoquinoline Derivatives as Antitumor Agents

被引:0
|
作者
Wang, Dao-Cai [1 ]
Song, Hang [1 ]
Yao, Shun [1 ]
机构
[1] Sichuan Univ, Dept Pharmaceut & Biol Engn, Chengdu 610065, Peoples R China
关键词
Synthesis; Tetrahydroisoquinoline derivatives; Antitumour activity;
D O I
10.14233/ajchem.2014.16064
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Fifteen novel tetrahydroisoquinoline derivatives have been synthesized via a mild synthetic route. The structures of all the compounds were confirmed by 1 H NMR spectra, 13 C NMR spectra and mass spectra. Their antitumor activities were evaluated in four human tumor cell lines, including human colon carcinoma (HCT116), non-small cell lung cancer (H1975), human lung adenocarcinoma (A549) and human pancreatic cancer (BxPC-3). Among them, compounds 4i and 4j exhibited remarkable growth inhibitory activity against the subtotal tested subpanel tumor cell lines particularly H1975 with GI values of 59.1 and 63.0 %, respectively.
引用
收藏
页码:3493 / 3495
页数:3
相关论文
共 50 条
  • [1] Design, synthesis, and biological antitumor evaluation of tetrahydroisoquinoline derivatives
    Pang, Can
    Zhao, Jianbo
    Zhang, Shuai
    Chen, Jiayu
    Zeng, Xiu
    Li, Hao
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 109
  • [2] Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate
    Zhu, Panhu
    Ye, Wenfeng
    Li, Jiaming
    Zhang, Yanchun
    Huang, Weijun
    Cheng, Mohan
    Wang, Yujun
    Zhang, Yang
    Liu, Huicai
    Zuo, Jian
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 89 (03) : 443 - 455
  • [3] Synthesis and biological evaluation of novel pazopanib derivatives as antitumor agents
    Qi, Haofei
    Chen, Ligong
    Liu, Bingni
    Wang, Xinran
    Long, Li
    Liu, Dengke
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (04) : 1108 - 1110
  • [4] Synthesis and Biological Evaluation of Novel Phenothiazine Derivatives as Potential Antitumor Agents
    Venkatesan, K.
    Satyanarayana, V. S. V.
    Sivakumar, A.
    [J]. POLYCYCLIC AROMATIC COMPOUNDS, 2023, 43 (01) : 850 - 859
  • [5] SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PHOSPHONATES DERIVATIVES OF AS POTENTIAL ANTITUMOR AGENTS
    Jin, Chuanfei
    Liang, Yong-Ju
    He, Hongwu
    Fu, Liwu
    [J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (10) : 2096 - 2103
  • [6] Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents
    Zhang, Bo
    Guo, Ruiying
    Hu, Yongzhou
    Dong, Xiaowu
    Lin, Nengming
    Dai, Xiaoyang
    Wu, Honghai
    Ma, Shenglin
    Yang, Bo
    [J]. RSC ADVANCES, 2017, 7 (51): : 31899 - 31906
  • [7] Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
    Xie, Yong-Mei
    Deng, Yi
    Dai, Xiao-Yun
    Liu, Jie
    Ouyang, Liang
    Wei, Yu-Quan
    Zhao, Ying-Lan
    [J]. MOLECULES, 2011, 16 (03) : 2519 - 2526
  • [8] Synthesis and biological evaluation of novel indoleamide derivatives as antioxidative and antitumor agents
    Zhang, Zhen
    Gu, Ying-Lin
    Wang, Zheng-Yang
    Wang, Huan-Nan
    Zhao, Yan
    Chu, Xue-Mei
    Zhang, Chun-Yan
    Yan, Mao-Cai
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (03) : 1165 - 1172
  • [9] Synthesis and biological evaluation of novel acylhydrazone derivatives as potential antitumor agents
    Congiu, Cenzo
    Onnis, Valentina
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (21) : 6592 - 6599