Synthesis and anti-inflammatory activity of N-arylamides of 4-aryl- and 4-(thiophen-2-yl)-2-[2-(furan-2-carbonyl)hydrazono]-4-oxobutanoic acids

被引：11
|
作者：
Igidov, S. N. [1 ,2 ]
Turyshev, A. Yu. [1 ]
Chashchina, S. V. [1 ,3 ]
Shipilovskikh, D. A. [4 ]
Chernov, I. N. [5 ]
Zvereva, O. V. [1 ]
Silaichev, P. S. [3 ]
Igidov, N. M. [1 ]
Shipilovskikh, S. A. [3 ,6 ]
机构：
[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, Perm State Pharmaceut Acad, 101 ul Ekaterininskaya, Perm 614990, Russia
[2] Merck LLC, 35 ul Vavilova, Moscow 115054, Russia
[3] Perm State Natl Res Univ, 15 Ul Bukireva, Perm 614990, Russia
[4] Perm Natl Res Polytech Univ, 29 Komsomolsky Prosp, Perm 614990, Russia
[5] Lobachevsky State Univ Nizhny Novgorod, Sci Res Inst Chem, 23 prosp Gagarina, Nizhnii Novgorod 603950, Russia
[6] ITMO Univ, Sch Phys & Engn, Build A,49 Kronverksky prosp, St Petersburg 197101, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 09期
关键词：
2,4-dioxobutanoic acids; 3-hydrazonofuran-2(3H)-ones; anti-inflammatory activity; ANTINOCICEPTIVE ACTIVITY; INTRAMOLECULAR CYCLIZATION; ANALGESIC ACTIVITY; INFLUENZA-VIRUS; DIKETO ACID; INHIBITION; ENDONUCLEASE; DERIVATIVES; DISCOVERY;
D O I：
10.1007/s11172-023-4021-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-Arylamides of 4-aryl/4-(thiophen-2-yl)-2-[2-(furan-2-carbonyl)hydrazono]-4-oxobutanoic acids were synthesized by the reaction of N & PRIME;-(5-aryl/5-(thiophen-2-yl)-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides with arylamines and evaluated for antiinflammatory activity.
引用
收藏
页码：2241 / 2248
页数：8
相关论文
共 50 条
  • [21] Synthesis, structure and antioxidant activity of 4-(2-isonicotinoylhydrazinyl)-4-oxobutanoic acid
    Nurkenov, O. A.
    Gazaliyev, A. M.
    Fazylov, S. D.
    Arinova, A. Ye.
    Seilkhanov, T. M.
    Karipova, G. Zh.
    Kabiyeva, S. K.
    Bakibayev, A. A.
    Takibayeva, A. T.
    Voronova, O. A.
    Plotnikov, Ye. V.
    BULLETIN OF THE UNIVERSITY OF KARAGANDA-CHEMISTRY, 2016, (83): : 16 - 21
  • [22] Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives
    Foroumadi, A
    Oboudiat, M
    Emami, S
    Karimollah, A
    Saghaee, L
    Moshafi, MH
    Shafiee, A
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (10) : 3421 - 3427
  • [23] Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids
    Gorbunova, I. A.
    Nikonov, I. P.
    Makhmudov, R. R.
    Shipilovskikh, D. A.
    Silaichev, P. S.
    Shipilovskikh, S. A.
    RUSSIAN CHEMICAL BULLETIN, 2023, 72 (09) : 2255 - 2262
  • [24] Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids
    I. A. Gorbunova
    I. P. Nikonov
    R. R. Makhmudov
    D. A. Shipilovskikh
    P. S. Silaichev
    S. A. Shipilovskikh
    Russian Chemical Bulletin, 2023, 72 : 2255 - 2262
  • [25] (4-Methylphenyl)[2-(thiophen-2-yl-carbonyl)phenyl]methanone
    Silambarasan, V.
    Sundaramoorthy, S.
    Sivasakthikumaran, R.
    MohanaKrishnan, A. K.
    Velmurugan, D.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2349 - U394
  • [26] Synthesis and electrochemical polymerization of a novel 2-(thiophen-2-yl)-4-(thiophen-2-ylmethylene)oxazol-5(4H)-one monomer for supercapacitor applications
    Hur, Evrim
    Arslan, Andac
    Hur, Deniz
    REACTIVE & FUNCTIONAL POLYMERS, 2016, 99 : 35 - 41
  • [27] DNA CLEAVAGE POTENTIAL OF 4-(PIPERIDIN-1-YLMETHYL)-2-(THIOPHEN-2-YL) QUINOLINE ANALOGUES
    Harishkumar, S.
    Satyanarayan, N. D.
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (03): : 2023 - 2026
  • [28] Chemistry of iminofurans: XI. Synthesis, structure, and cyclization of 4-substituted 2-(aroylhydrazinylidene)-4-oxobutanoic acids
    N. M. Igidov
    M. A. Kiselev
    A. E. Rubtsov
    Russian Journal of Organic Chemistry, 2016, 52 : 526 - 532
  • [29] Chemistry of iminofurans: XI. Synthesis, structure, and cyclization of 4-substituted 2-(aroylhydrazinylidene)-4-oxobutanoic acids
    Igidov, N. M.
    Kiselev, M. A.
    Rubtsov, A. E.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (04) : 526 - 532
  • [30] Synthesis and anti-Candidal activity of N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide
    Bhat, Mashooq Ahmad
    Khan, Abdul Arif
    Khan, Shahanavaj
    Al-Omar, Mohamed A.
    Parvez, Mohammad Khalid
    Al-Dosari, Mohammed Salem
    Al-Dhfyan, Abdullah
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (05) : 1299 - 1302
12345