Synthesis and anti-inflammatory activity of N-arylamides of 4-aryl- and 4-(thiophen-2-yl)-2-[2-(furan-2-carbonyl)hydrazono]-4-oxobutanoic acids

被引：11
|
作者：
Igidov, S. N. [1 ,2 ]
Turyshev, A. Yu. [1 ]
Chashchina, S. V. [1 ,3 ]
Shipilovskikh, D. A. [4 ]
Chernov, I. N. [5 ]
Zvereva, O. V. [1 ]
Silaichev, P. S. [3 ]
Igidov, N. M. [1 ]
Shipilovskikh, S. A. [3 ,6 ]
机构：
[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, Perm State Pharmaceut Acad, 101 ul Ekaterininskaya, Perm 614990, Russia
[2] Merck LLC, 35 ul Vavilova, Moscow 115054, Russia
[3] Perm State Natl Res Univ, 15 Ul Bukireva, Perm 614990, Russia
[4] Perm Natl Res Polytech Univ, 29 Komsomolsky Prosp, Perm 614990, Russia
[5] Lobachevsky State Univ Nizhny Novgorod, Sci Res Inst Chem, 23 prosp Gagarina, Nizhnii Novgorod 603950, Russia
[6] ITMO Univ, Sch Phys & Engn, Build A,49 Kronverksky prosp, St Petersburg 197101, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 09期
关键词：
2,4-dioxobutanoic acids; 3-hydrazonofuran-2(3H)-ones; anti-inflammatory activity; ANTINOCICEPTIVE ACTIVITY; INTRAMOLECULAR CYCLIZATION; ANALGESIC ACTIVITY; INFLUENZA-VIRUS; DIKETO ACID; INHIBITION; ENDONUCLEASE; DERIVATIVES; DISCOVERY;
D O I：
10.1007/s11172-023-4021-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-Arylamides of 4-aryl/4-(thiophen-2-yl)-2-[2-(furan-2-carbonyl)hydrazono]-4-oxobutanoic acids were synthesized by the reaction of N & PRIME;-(5-aryl/5-(thiophen-2-yl)-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides with arylamines and evaluated for antiinflammatory activity.
引用
收藏
页码：2241 / 2248
页数：8
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