A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU

被引：1
|
作者：
Preman, Pranav [1 ,2 ]
Arranz, Amaia M. [3 ,4 ]
机构：
[1] VIB Ctr Brain & Dis Res, Leuven, Belgium
[2] Univ Leuven, KU Leuven, Leuven Brain Inst LBI, Lab Res Neurodegenerat Dis,Dept Neurosci, Leuven, Belgium
[3] Achucarro Basque Ctr Neurosci, Leioa, Spain
[4] Ikerbasque Basque Fdn Sci, Bilbao, Spain
来源：
CELL REPORTS | 2023年 / 42卷 / 09期
关键词：
D O I：
10.1016/j.celrep.2023.113129
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lee et al.1 report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Ab levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Identification of Alzheimer Disease Risk Genotype That Predicts Efficiency of SORL1 Expression in the Brain
    Caglayan, Safak
    Bauerfeind, Anja
    Schmidt, Vanessa
    Carlo, Anne-Sophie
    Prabakaran, Thaneas
    Huebner, Norbert
    Willnow, Thomas E.
    ARCHIVES OF NEUROLOGY, 2012, 69 (03) : 373 - 379
  • [42] Biallelic Loss of Function of SORL1 in an Early Onset Alzheimer's Disease Patient
    Le Guennec, Kilan
    Tubeuf, Helene
    Hannequin, Didier
    Wallon, David
    Quenez, Olivier
    Rousseau, Stephane
    Richard, Anne-Claire
    Deleuze, Jean-Francois
    Boland, Anne
    Frebourg, Thierry
    Gaildrat, Pascaline
    Campion, Dominique
    Martins, Alexandra
    Nicolas, Gael
    JOURNAL OF ALZHEIMERS DISEASE, 2018, 62 (02) : 821 - 831
  • [43] SORL1 Mutations in Early and Late Onset Alzheimer's Disease in Saudi Patients
    Alrajeh, Saad M.
    AlTassan, Nada
    Qadi, Najeeb
    Abdulaziz, Sara
    Majrashi, Nada
    Alinizi, Maznah
    Elbitar, Fadia
    ANNALS OF NEUROLOGY, 2017, 82 : S35 - S35
  • [44] SORL1 and White Matter Tract Integrity: Predicting Risk for Late-Onset Alzheimer's Disease
    Felsky, Daniel
    Lerch, Jason
    Chakravarty, Mallar M.
    Pipitone, Jon
    Rajji, Tarek K.
    Lobaugh, Nancy J.
    Mulsant, Benoit H.
    Pollock, Bruce G.
    Kennedy, James L.
    Voineskos, Aristotle N.
    BIOLOGICAL PSYCHIATRY, 2012, 71 (08) : 150S - 150S
  • [45] Alzheimer's disease β-secretase BACE1 is not a neuron-specific enzyme
    Rossner, S
    Lange-Dohna, C
    Zeitschel, U
    Perez-Polo, JR
    JOURNAL OF NEUROCHEMISTRY, 2005, 92 (02) : 226 - 234
  • [46] SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease
    Nicolas, G.
    Charbonnier, C.
    Wallon, D.
    Quenez, O.
    Bellenguez, C.
    Grenier-Boley, B.
    Rousseau, S.
    Richard, A-C
    Rovelet-Lecrux, A.
    Le Guennec, K.
    Bacq, D.
    Garnier, J-G
    Olaso, R.
    Boland, A.
    Meyer, V.
    Deleuze, J-F
    Amouyel, P.
    Munter, H. M.
    Bourque, G.
    Lathrop, M.
    Frebourg, T.
    Redon, R.
    Letenneur, L.
    Dartigues, J-F
    Genin, E.
    Lambert, J-C
    Hannequin, D.
    Campion, D.
    MOLECULAR PSYCHIATRY, 2016, 21 (06) : 831 - 836
  • [47] The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia
    Mishra, Swati
    Morshed, Nader
    Sidhu, Sonia Beant
    Kinoshita, Chizuru
    Stevens, Beth
    Jayadev, Suman
    Young, Jessica E.
    GLIA, 2025,
  • [48] Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease
    Lee, J. H.
    Cheng, R.
    Honig, L. S.
    Vonsattel, J. -P. G.
    Clark, L.
    Mayeux, R.
    NEUROLOGY, 2008, 70 (11) : 887 - 889
  • [49] The Alzheimer's disease β-secretase (BACE1) is not a neuron-specific enzyme
    Rossner, S
    Hartlage-Rübsamen, M
    Lange-Dohna, C
    Zeitschel, U
    Bigl, V
    JOURNAL OF NEUROCHEMISTRY, 2003, 85 : 98 - 98
  • [50] The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer's disease
    dos Santos, Ligia Ramos
    Figueiredo Almeida, Jucimara Ferreira
    Sagrillo Pimassoni, Lucia Helena
    Morelato, Renato Lirio
    de Paula, Flavia
    GENETICS AND MOLECULAR BIOLOGY, 2020, 43 (01) : 1 - 7
12345