A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU

被引：1
|
作者：
Preman, Pranav [1 ,2 ]
Arranz, Amaia M. [3 ,4 ]
机构：
[1] VIB Ctr Brain & Dis Res, Leuven, Belgium
[2] Univ Leuven, KU Leuven, Leuven Brain Inst LBI, Lab Res Neurodegenerat Dis,Dept Neurosci, Leuven, Belgium
[3] Achucarro Basque Ctr Neurosci, Leioa, Spain
[4] Ikerbasque Basque Fdn Sci, Bilbao, Spain
来源：
CELL REPORTS | 2023年 / 42卷 / 09期
关键词：
D O I：
10.1016/j.celrep.2023.113129
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lee et al.1 report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Ab levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Interaction between PPAR γ and SORL1 gene with Late-Onset Alzheimer's disease in Chinese Han Population
    Zhang Hui
    Zheng Wei
    Hua Linlin
    Wang Yutong
    Li Jinfeng
    Bai Hongying
    Wang Shanshan
    Du Mingyao
    Ma Xuelian
    Xu Chunyang
    Li Xiaodong
    Gong Bin
    Wang Yunliang
    ONCOTARGET, 2017, 8 (29) : 48313 - 48320
  • [22] Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease
    Olav M. Andersen
    Ina-Maria Rudolph
    Thomas E. Willnow
    Acta Neuropathologica, 2016, 132 : 653 - 665
  • [23] A Study of the SORL1 Gene in Alzheimer's Disease and Cognitive Function
    Liu, Fan
    Ikram, M. Arfan
    Janssens, A. Cecile J. W.
    Schuur, Maaike
    de Koning, Inge
    Isaacs, Aaron
    Struchalin, Maksim
    Uitterlinden, Andre G.
    den Dunnen, Johan T.
    Sleegers, Kristel
    Bettens, Karolien
    Van Broeckhoven, Christine
    van Swieten, John
    Hofman, Albert
    Oostra, Ben A.
    Aulchenko, Yurii S.
    Breteler, Monique M. B.
    van Duijn, Cornelia M.
    JOURNAL OF ALZHEIMERS DISEASE, 2009, 18 (01) : 51 - 64
  • [24] Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease
    Andersen, Olav M.
    Rudolph, Ina-Maria
    Willnow, Thomas E.
    ACTA NEUROPATHOLOGICA, 2016, 132 (05) : 653 - 665
  • [25] Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease
    Reitz, Christiane
    Cheng, Rong
    Rogaeva, Ekaterina
    Lee, Joseph H.
    Tokuhiro, Shinya
    Zou, Fanggeng
    Bettens, Karolien
    Sleegers, Kristel
    Tan, Eng King
    Kimura, Ryo
    Shibata, Nobuto
    Arai, Heii
    Kamboh, M. Ilyas
    Prince, Jonathan A.
    Maier, Wolfgang
    Riemenschneider, Matthias
    Owen, Michael
    Harold, Denise
    Hollingworth, Paul
    Cellini, Elena
    Sorbi, Sandro
    Nacmias, Benedetta
    Takeda, Masatoshi
    Pericak-Vance, Margaret A.
    Haines, Jonathan L.
    Younkin, Steven
    Williams, Julie
    van Broeckhoven, Christine
    Farrer, Lindsay A.
    St George-Hyslop, Peter H.
    Mayeux, Richard
    ARCHIVES OF NEUROLOGY, 2011, 68 (01) : 99 - 106
  • [26] The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan
    Felsky, D.
    Szeszko, P.
    Yu, L.
    Honer, W. G.
    De Jager, P. L.
    Schneider, J. A.
    Malhotra, A. K.
    Lencz, T.
    Ikuta, T.
    Pipitone, J.
    Chakravarty, M. M.
    Lobaugh, N. J.
    Mulsant, B. H.
    Pollock, B. G.
    Kennedy, J. L.
    Bennett, D. A.
    Voineskos, A. N.
    MOLECULAR PSYCHIATRY, 2014, 19 (10) : 1125 - 1132
  • [27] SORL1 variants across Alzheimer’s disease European American cohorts
    Maria Victoria Fernández
    Kathleen Black
    David Carrell
    Ben Saef
    John Budde
    Yuetiva Deming
    Bill Howells
    Jorge L Del-Aguila
    Shengmei Ma
    Catherine Bi
    Joanne Norton
    Rachel Chasse
    John Morris
    Alison Goate
    Carlos Cruchaga
    European Journal of Human Genetics, 2016, 24 : 1828 - 1830
  • [28] The role of LR11/SORL1 in Alzheimer's disease pathogenesis
    Lah, James J.
    ANNALS OF NEUROLOGY, 2007, 62 : S1 - S1
  • [29] SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease
    Guo, Liang-Hao
    Westerteicher, Christine
    Wang, Xin-Hui
    Kratzer, Martina
    Tsolakidou, Amalia
    Jiang, Meizi
    Grimmer, Timo
    Laws, Simon M.
    Alexopoulos, Panagiotis
    Bujo, Hideaki
    Kurz, Alexander
    Perneczky, Robert
    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2012, 262 (06) : 529 - 534
  • [30] EXPLORING A LINK BETWEEN ALZHEIMER'S AND GLIOMA BY INVESTIGATING SORL1 NETWORK
    Montalbo, Kristy
    Bakker, Emyr
    Stasik, Izabela
    Smith, Christopher
    NEURO-ONCOLOGY, 2022, 24 : 22 - 22
12345