A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU

被引：1

作者：

Preman, Pranav ^{[1
,2
]}

Arranz, Amaia M. ^{[3
,4
]}

机构：

[1] VIB Ctr Brain & Dis Res, Leuven, Belgium

[2] Univ Leuven, KU Leuven, Leuven Brain Inst LBI, Lab Res Neurodegenerat Dis,Dept Neurosci, Leuven, Belgium

[3] Achucarro Basque Ctr Neurosci, Leioa, Spain

[4] Ikerbasque Basque Fdn Sci, Bilbao, Spain

来源：

CELL REPORTS | 2023年 / 42卷 / 09期

关键词：

D O I：

10.1016/j.celrep.2023.113129

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lee et al.1 report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Ab levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.

引用

页数：2

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