A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU

被引：1
|
作者：
Preman, Pranav [1 ,2 ]
Arranz, Amaia M. [3 ,4 ]
机构：
[1] VIB Ctr Brain & Dis Res, Leuven, Belgium
[2] Univ Leuven, KU Leuven, Leuven Brain Inst LBI, Lab Res Neurodegenerat Dis,Dept Neurosci, Leuven, Belgium
[3] Achucarro Basque Ctr Neurosci, Leioa, Spain
[4] Ikerbasque Basque Fdn Sci, Bilbao, Spain
来源：
CELL REPORTS | 2023年 / 42卷 / 09期
关键词：
D O I：
10.1016/j.celrep.2023.113129
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lee et al.1 report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Ab levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1
    Lee, Hyo
    Aylward, Aimee J.
    Pearse II, Richard, V
    Lish, Alexandra M.
    Hsieh, Yi-Chen
    Augur, Zachary M.
    Benoit, Courtney R.
    Chou, Vicky
    Knupp, Allison
    Pan, Cheryl
    Goberdhan, Srilakshmi
    Duong, Duc M.
    Seyfried, Nicholas T.
    Bennett, David A.
    Taga, Mariko F.
    Huynh, Kevin
    Arnold, Matthias
    Meikle, Peter J.
    De Jager, Philip L.
    Menon, Vilas
    Young, Jessica E.
    Young-Pearse, Tracy L.
    CELL REPORTS, 2023, 42 (08):
  • [2] Association between SORL1 polymorphisms and the risk of Alzheimer's disease
    Cong, Lele
    Kong, Xiangyi
    Wang, Jing
    Du, Jianshi
    Xu, Zhongxin
    Xu, Yanan
    Zhao, Qing
    JOURNAL OF INTEGRATIVE NEUROSCIENCE, 2018, 17 (02) : 185 - 192
  • [3] The Role of SORL1 in Alzheimer’s Disease
    Rui-Hua Yin
    Jin-Tai Yu
    Lan Tan
    Molecular Neurobiology, 2015, 51 : 909 - 918
  • [4] The Role of SORL1 in Alzheimer's Disease
    Yin, Rui-Hua
    Yu, Jin-Tai
    Tan, Lan
    MOLECULAR NEUROBIOLOGY, 2015, 51 (03) : 909 - 918
  • [5] SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese
    Tan, E. K.
    Lee, J.
    Chen, C. P.
    Teo, Y. Y.
    Zhao, Y.
    Lee, W. L.
    NEUROBIOLOGY OF AGING, 2009, 30 (07) : 1048 - 1051
  • [6] SORL1 mutations in familial Alzheimer's disease
    Ruggiero, M.
    Aguero Rabes, P.
    Sainz Artiga, M. J.
    Prieto-Jurczynska, C.
    Venegas, M. B.
    Ordas-Bandera, C.
    Guerrero, R.
    Perez-Perez, J.
    Gomez-Tortosa, E.
    EUROPEAN JOURNAL OF NEUROLOGY, 2017, 24 : 241 - 241
  • [7] Sorl1 as an Alzheimer's disease predisposition gene?
    Webster, Jennifer A.
    Myers, AmandaJ.
    Pearson, John V.
    Craig, David W.
    Diane, Hu-Lincea
    Coon, Keith D.
    Zismann, Victoria L.
    Beach, Thomas
    Leunge, Doris
    Bryden, Leslie
    Halperin, Rebecca F.
    Marlowe, Lauren
    Kaleem, Mona
    Huentelman, Matthew J.
    Joshipura, Keta
    Walker, Douglas
    Heward, Christopher B.
    Ravidi, Rivka
    Rogers, Joseph
    Papassotiropoulos, Andreas
    Hardy, John
    Reiman, Eric M.
    Stephan, Dietrich A.
    NEURODEGENERATIVE DISEASES, 2008, 5 (02) : 60 - 64
  • [8] Possible Association between SORL1 and Alzheimer Disease?
    Lee, Joseph H.
    Shibata, Nobuto
    Cheng, Rong
    Mayeux, Richard
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2008, 26 (05) : 482 - 482
  • [9] No association of SORL1 SNPs with Alzheimer's disease
    Minster, Ryan L.
    DeKosky, Steven T.
    Kamboh, M. Ilyas
    NEUROSCIENCE LETTERS, 2008, 440 (02) : 190 - 192
  • [10] SORL1 Variants in Familial Alzheimer's Disease
    Gomez-Tortosa, Estrella
    Ruggiero, Maria
    Jose Sainz, Ma
    Villarejo-Galende, Alberto
    Prieto-Jurczynska, Cristina
    Venegas Perez, Begona
    Ordas, Carlos
    Aguero, Pablo
    Guerrero-Lopez, Rosa
    Perez-Perez, Julian
    JOURNAL OF ALZHEIMERS DISEASE, 2018, 61 (04) : 1275 - 1280
12345