Electrochemical monofluoroalkylation cyclization of N-arylacrylamides to construct monofluorinated 2-oxindoles

被引：19

作者：

Lv, Yanxia ^{[1
,2
,3
]}

Hou, Zhong-Wei ^{[1
,2
]}

Wang, Yi ^{[4
]}

Li, Pinhua ^{[3
]}

Wang, Lei ^{[1
,2
,3
,4
]}

机构：

[1] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut Sci, Taizhou 318000, Peoples R China

[3] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China

[4] Anhui Med Univ, Hosp 2, Hefei 230601, Anhui, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 05期

基金：

中国国家自然科学基金;

关键词：

FLUORINATED 3,3-DISUBSTITUTED 2-OXINDOLES; C-H FUNCTIONALIZATION; RADICAL CYCLIZATION; CATALYST-FREE; ACCESS; BENZYLACRYLAMIDES; DERIVATIVES; TRIFLUOROMETHYLATION/CYCLIZATION; SPIROCYCLIZATION; OXINDOLES;

D O I：

10.1039/d2ob01883g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An electrochemical monofluoroalkylation cyclization of N-arylacrylamides to synthesize monofluorinated 2-oxindoles has been developed, which employs common dimethyl 2-fluoromalonate as a monofluoroalkyl radical precursor and obviates the use of prefunctionalized monofluoroalkylation reagents and sacrificial oxidants. A variety of monofluorinated nitrogen-containing heterocyclic compounds were efficiently obtained with satisfactory yields from readily available materials.

引用

页码：1014 / 1020

页数：7

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