Transition metal-free synthesis of fluoroalkylated oxindoles via base-mediated fluoroalkylation of N-arylacrylamides with RFI

被引：12
|
作者：
Yang, Zhiyong [1 ]
Cheng, Yuanyuan [1 ]
Long, Jikun [1 ]
Feng, Xiaoying [1 ]
Tang, Rong [1 ]
Wei, Jinmei [1 ]
机构：
[1] Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 47期
关键词：
HECK-TYPE REACTION; PHOTOREDOX CATALYSIS; UNACTIVATED ALKENES; RADICAL TRIFLUOROMETHYLATION; DIFLUOROMETHYLATED ARENES; CONCOMITANT INTRODUCTION; PERFLUOROALKYL RADICALS; ACTIVATED ALKENES; ARYL HALIDES; HYDROTRIFLUOROMETHYLATION;
D O I：
10.1039/c9nj04458b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A base-mediated tandem radical procedure for the synthesis of fluoroalkylated oxindoles via the cyclization reaction of N-arylacrylamides with RFI was developed. With this facile and practical synthetic method, a wide range of 3-(2-perfluoroalkyl)indolin-2-ones could be obtained in good yields with high stereoselectivity.
引用
收藏
页码：18760 / 18766
页数：7
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