Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl Bromides

被引：42

作者：

Du, Juan ^{[1
,2
]}

Wang, Xing ^{[1
]}

Wang, Hongling ^{[1
]}

Wei, Jinhu ^{[1
]}

Huang, Xuan ^{[1
]}

Song, Jun ^{[2
]}

Zhang, Junmin ^{[1
]}

机构：

[1] Shenzhen Univ, Coll Chem & Environm Engn, Int Joint Res Ctr Mol Sci, Shenzhen 518060, Peoples R China

[2] Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 15期

基金：

中国国家自然科学基金;

关键词：

BOND FORMATION; COMPLEXES; OXIDATION;

D O I：

10.1021/acs.orglett.1c01698

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild visible-light-induced Pd-catalyzed intermolecular radical cascade reaction of N- arylacrylamides with unactivated alkyl bromides is disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid alkyl Pd-radical species are involved as the key reaction intermediates. Sophisticated bioactive oxindole derivatives bearing various substituents and substitution patterns can be efficiently afforded through this approach.

引用

页码：5631 / 5635

页数：5

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