Cobalt and iron bis(dicarbollide) conjugates with cholesterol: synthesis and evaluation of antiproliferative activity

被引：3

作者：

Erdelyi, K. E. ^{[1
,2
]}

Antonets, A. A. ^{[3
]}

Zhidkova, O. B. ^{[1
]}

Druzina, A. A. ^{[1
]}

Nazarov, A. A. ^{[3
]}

Timofeev, S. V. ^{[1
,3
]}

Sivaev, I. B. ^{[1
]}

Bregadze, V. I. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28-1 Ul Vavilova, Moscow 119334, Russia

[2] Natl Res Univ Higher Sch Econ, 20 Ul Myasnitskaya, Moscow 101000, Russia

[3] Moscow MV Lomonosov State Univ, 1-3 Leninskiye Gory, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 04期

关键词：

cobalt; iron bis(dicarbollide); cholesterol; lipids; click reaction; boron neutron capture therapy; BORON-RICH LIPOSOMES; THERAPEUTIC-EFFICACY; NIDO-CARBORANE; DRUG-DELIVERY; LIVING CELLS; DERIVATIVES; COSAN; TRANSITION;

D O I：

10.1007/s11172-023-3871-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Boron-containing conjugates of cholesterol were synthesized by the copper(i)-catalyzed 1,3-dipolar [3+2] cycloaddition reactions of cobalt and iron bis(dicarbollide) azide derivatives with alkynyl cholesterol. The antiproliferative activity (IC50) of the conjugates was evaluated against a series of human cell lines by the MTT assay. All conjugates were shown to be nontoxic (IC50 >200 mu mol L-1) and to be applicable for the preparation of boron-containing liposomes as potential drugs for boron-neutron capture therapy (BNCT) of cancer.

引用

页码：1059 / 1065

页数：7

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