Cobalt and iron bis(dicarbollide) conjugates with cholesterol: synthesis and evaluation of antiproliferative activity

被引：3
|
作者：
Erdelyi, K. E. [1 ,2 ]
Antonets, A. A. [3 ]
Zhidkova, O. B. [1 ]
Druzina, A. A. [1 ]
Nazarov, A. A. [3 ]
Timofeev, S. V. [1 ,3 ]
Sivaev, I. B. [1 ]
Bregadze, V. I. [1 ]
机构：
[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28-1 Ul Vavilova, Moscow 119334, Russia
[2] Natl Res Univ Higher Sch Econ, 20 Ul Myasnitskaya, Moscow 101000, Russia
[3] Moscow MV Lomonosov State Univ, 1-3 Leninskiye Gory, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 04期
关键词：
cobalt; iron bis(dicarbollide); cholesterol; lipids; click reaction; boron neutron capture therapy; BORON-RICH LIPOSOMES; THERAPEUTIC-EFFICACY; NIDO-CARBORANE; DRUG-DELIVERY; LIVING CELLS; DERIVATIVES; COSAN; TRANSITION;
D O I：
10.1007/s11172-023-3871-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Boron-containing conjugates of cholesterol were synthesized by the copper(i)-catalyzed 1,3-dipolar [3+2] cycloaddition reactions of cobalt and iron bis(dicarbollide) azide derivatives with alkynyl cholesterol. The antiproliferative activity (IC50) of the conjugates was evaluated against a series of human cell lines by the MTT assay. All conjugates were shown to be nontoxic (IC50 >200 mu mol L-1) and to be applicable for the preparation of boron-containing liposomes as potential drugs for boron-neutron capture therapy (BNCT) of cancer.
引用
收藏
页码：1059 / 1065
页数：7
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