Cobalt and iron bis(dicarbollide) conjugates with cholesterol: synthesis and evaluation of antiproliferative activity

被引：3

作者：

Erdelyi, K. E. ^{[1
,2
]}

Antonets, A. A. ^{[3
]}

Zhidkova, O. B. ^{[1
]}

Druzina, A. A. ^{[1
]}

Nazarov, A. A. ^{[3
]}

Timofeev, S. V. ^{[1
,3
]}

Sivaev, I. B. ^{[1
]}

Bregadze, V. I. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28-1 Ul Vavilova, Moscow 119334, Russia

[2] Natl Res Univ Higher Sch Econ, 20 Ul Myasnitskaya, Moscow 101000, Russia

[3] Moscow MV Lomonosov State Univ, 1-3 Leninskiye Gory, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 04期

关键词：

cobalt; iron bis(dicarbollide); cholesterol; lipids; click reaction; boron neutron capture therapy; BORON-RICH LIPOSOMES; THERAPEUTIC-EFFICACY; NIDO-CARBORANE; DRUG-DELIVERY; LIVING CELLS; DERIVATIVES; COSAN; TRANSITION;

D O I：

10.1007/s11172-023-3871-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Boron-containing conjugates of cholesterol were synthesized by the copper(i)-catalyzed 1,3-dipolar [3+2] cycloaddition reactions of cobalt and iron bis(dicarbollide) azide derivatives with alkynyl cholesterol. The antiproliferative activity (IC50) of the conjugates was evaluated against a series of human cell lines by the MTT assay. All conjugates were shown to be nontoxic (IC50 >200 mu mol L-1) and to be applicable for the preparation of boron-containing liposomes as potential drugs for boron-neutron capture therapy (BNCT) of cancer.

引用

页码：1059 / 1065

页数：7

共 50 条

[31] Synthesis and Antiproliferative Activity of Silybin Conjugates with Salinomycin and Monensin
Antoszczak, Michal
Klejborowska, Greta
Kruszyk, Monika
Maj, Ewa
Wietrzyk, Joanna
Huczynski, Adam
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 86 (06) : 1378 - 1386
[32] Synthesis of cobalt bis(8-methylthio-1,2-dicarbollide)- pentacarbonyltungsten complexes
S. V. Timofeev
S. A. Anufriev
I. B. Sivaev
V. I. Bregadze
Russian Chemical Bulletin, 2018, 67 : 570 - 572
[33] Synthesis of hetero-substituted derivatives of cobalt bis(1,2-dicarbollide)
I. D. Kosenko
I. A. Lobanova
I. B. Sivaev
P. V. Petrovskii
V. I. Bregadze
Russian Chemical Bulletin, 2011, 60 : 2354 - 2358
[34] Synthesis of cobalt bis(8-methylthio-1,2-dicarbollide)-pentacarbonyltungsten complexes
Timofeev, S. V.
Anufriev, S. A.
Sivaev, I. B.
Bregadze, V. I.
RUSSIAN CHEMICAL BULLETIN, 2018, 67 (03) : 570 - 572
[35] Synthesis of hetero-substituted derivatives of cobalt bis(1,2-dicarbollide)
Kosenko, I. D.
Lobanova, I. A.
Sivaev, I. B.
Petrovskii, P. V.
Bregadze, V. I.
RUSSIAN CHEMICAL BULLETIN, 2011, 60 (11) : 2354 - 2358
[36] Rodlike Polymers Containing Nickel and Cobalt Metal Bis(dicarbollide) Anions: Synthesis and Characterization
Pichaandi, Kothanda Rama
Safronov, Alexander V.
Sevryugina, Yulia V.
Everett, Thomas A.
Jalisatgi, Satish S.
Hawthorne, M. Frederick
ORGANOMETALLICS, 2017, 36 (19) : 3823 - 3829
[37] Synthesis of functional derivatives of cobalt bis(1,2-dicarbollide) anion for BNCT
Bregadze, V
Sívaev, I
Sjöberg, S
RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY, 2002, : 13 - 17
[38] Synthesis, Characterization and Kinetic Release Profile of Iron Containing Polymeric Co-conjugates with Antiproliferative Activity
B. D. Nkazi
E. W. Neuse
E. R. Sadiku
B. A. Aderibigbe
Journal of Inorganic and Organometallic Polymers and Materials, 2014, 24 : 302 - 314
[39] Synthesis, Characterization and Kinetic Release Profile of Iron Containing Polymeric Co-conjugates with Antiproliferative Activity
Nkazi, B. D.
Neuse, E. W.
Sadiku, E. R.
Aderibigbe, B. A.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2014, 24 (02) : 302 - 314
[40] Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates
George, Alex
Raji, Idris
Cinar, Bekir
Kucuk, Omer
Oyelere, Adegboyega K.
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (08) : 1481 - 1487

← 1 2 3 4 5 →