Rationale and design of the ABOARD project (A Personalized Medicine Approach for Alzheimer's Disease)

被引:9
|
作者
Dreves, Maria A. E. [1 ,2 ]
van Harten, Argonde [1 ,2 ,3 ]
Visser, Leonie N. C. [1 ,4 ,5 ,6 ]
Rhodius-Meester, Hanneke [1 ,7 ,8 ]
Kohler, Sebastian [9 ]
Kooistra, Minke M. [10 ]
Papma, Janne [11 ,12 ]
Honey, Madison I. J. M. [2 ,3 ]
Blom, Marco M. [10 ]
Smets, Ellen M. A. [4 ,5 ]
de Vugt, Marjolein E.
Teunissen, Charlotte E. [2 ,3 ]
van der Flier, Wiesje [1 ,2 ,9 ,13 ,14 ]
机构
[1] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC locat VUmc, Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC locat VUmc, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam, Netherlands
[4] Univ Amsterdam, Dept Med Psychol, Amsterdam UMC locat AMC, Amsterdam, Netherlands
[5] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Qual Care, Amsterdam UMC locat AMC, Amsterdam, Netherlands
[6] Karolinska Inst, Div Clin Geriat, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
[7] Vrije Univ Amsterdam, Dept Internal Med, Geriat Med Sect, Amsterdam, Netherlands
[8] Oslo Univ Hosp, Dept Geriat Med, Memory Clin, Oslo, Norway
[9] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
[10] Alzheimer Nederland, Amersfoort, Netherlands
[11] Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
[12] Erasmus MC Univ Med Ctr, Alzheimer Ctr Erasmus MC, Rotterdam, Netherlands
[13] Vrije Univ Amsterdam, Dept Epidemiol & Data Sci, Amsterdam UMC locat VUmc, Amsterdam, Netherlands
[14] Amsterdam UMC locat VUmc, Alzheimer Ctr Amsterdam, PK 1Z44, Boelelaan 1118, NL-1081 HZ Amsterdam, Netherlands
关键词
Alzheimer's disease; diagnosis; patient-orchestrated care; personalized medicine; prediction; prevention; PREVENTION;
D O I
10.1002/trc2.12401
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The key to stopping Alzheimer's disease (AD) lies in the pre-dementia stages, with the goal to stop AD before dementia has started. We present the rationale and design of the ABOARD (A Personalized Medicine Approach for Alzheimer's Disease) project, which aims to invest in personalized medicine for AD. ABOARD is a Dutch public-private partnership of 32 partners, connecting stakeholders from a scientific, clinical, and societal perspective. The 5-year project is structured into five work packages on (1) diagnosis, (2) prediction, (3) prevention, (4) patient-orchestrated care, and (5) communication and dissemination. ABOARD functions as a network organization in which professionals interact cross-sectorally. ABOARD has a strong junior training program "Juniors On Board." Project results are shared with society through multiple communication resources. By including relevant partners and involving citizens at risk, patients, and their care partners, ABOARD builds toward a future with personalized medicine for AD. HighlightsABOARD (A Personalized Medicine Approach for Alzheimer's Disease) is a public-private research project executed by 32 partners that functions as a network organization.Together, the project partners build toward a future with personalized medicine for Alzheimer's disease.Although ABOARD is a Dutch consortium, it has international relevance.ABOARD improves diagnosis, prediction, prevention, and patient-orchestrated care.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] Study Design for a Multi-Modal Approach to Understanding Parkinson's Disease: The Personalized Parkinson Project
    Marks, W., Jr.
    Evers, L.
    Faber, M.
    Verbeek, M.
    de Vries, N.
    Bloem, B.
    MOVEMENT DISORDERS, 2017, 32
  • [22] Personalized Medicine and Resurrected Hopes for the Management of Alzheimer's Disease: A Modular Approach Based on GSK-3β Inhibitors
    Arafa, Reem K.
    Elghazawy, Nehal H.
    PERSONALISED MEDICINE: LESSONS FROM NEURODEGENERATION TO CANCER, 2017, 1007 : 199 - 224
  • [23] Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer's Disease
    Ryu, Woo-In
    Cohen, Bruce M.
    Sonntag, Kai-C.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [24] Biomarker-guided drug therapy: personalized medicine for treating Alzheimer's disease
    Charvi Syal
    Jing Wang
    Neural Regeneration Research, 2021, 16 (10) : 2010 - 2011
  • [25] Biomarker-guided drug therapy: personalized medicine for treating Alzheimer's disease
    Syal, Charvi
    Wang, Jing
    NEURAL REGENERATION RESEARCH, 2021, 16 (10) : 2010 - 2011
  • [26] The Rationale for Radiation Therapy in Alzheimer's Disease
    Wilson, George D.
    Rogers, C. Leland
    Mehta, Minesh P.
    Marples, Brian
    Michael, Daniel B.
    Welsh, James S.
    Martinez, Alvaro A.
    Fontanesia, James
    RADIATION RESEARCH, 2023, 199 (05) : 506 - 516
  • [27] Rationale for the development of an Alzheimer?s disease vaccine
    Kwan, Ping
    Konno, Haruki
    Chan, Ka Yan
    Baum, Larry
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2020, 16 (03) : 645 - 653
  • [28] The Rationale for Insulin Therapy in Alzheimer's Disease
    Ribaric, Samo
    MOLECULES, 2016, 21 (06):
  • [29] Background and rationale for the management of Alzheimer's disease
    Burns, A.
    EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 : 323 - 323
  • [30] Treatment of Alzheimer's disease - Rationale and strategies
    Grundman, M
    Thal, LJ
    NEUROLOGIC CLINICS, 2000, 18 (04) : 807 - +