The Rationale for Radiation Therapy in Alzheimer's Disease

被引：6

作者：

Wilson, George D. ^{[1
]}

Rogers, C. Leland ^{[2
]}

Mehta, Minesh P. ^{[3
]}

Marples, Brian ^{[4
]}

Michael, Daniel B. ^{[5
]}

Welsh, James S. ^{[6
]}

Martinez, Alvaro A. ^{[7
]}

Fontanesia, James ^{[1
]}

机构：

[1] William Beaumont Hosp, Radiat Oncol, Royal Oak, MI USA

[2] GammaWest Canc Serv, Radiat Oncol, Salt Lake City, UT USA

[3] Baptist Hlth Miami Canc Inst, Radiat Oncol, Miami, FL USA

[4] Univ Rochester, Dept Radiat Oncol, New York, NY USA

[5] William Beaumont Hosp, Dept Neurosurg, Royal Oak, MI USA

[6] Loyola Univ Chicago, Dept Radiat Oncol, Maywood, IL USA

[7] GenesisCare, Pontiac, MI USA

来源：

RADIATION RESEARCH | 2023年 / 199卷 / 05期

关键词：

BETA-AMYLOID PLAQUES; IMPROVES COGNITION; MURINE MODEL; BRAIN; IRRADIATION;

D O I：

10.1667/RADE-22-00179.1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alzheimer's Disease (AD) represents a major health problem without effective treatments. As the incidence of the disease will continue to rise, it is imperative to find new treatment options to halt or slow disease progression. In recent years, several groups have begun to study the utility of low total dose radiation therapy (LTDRT) to inhibit some of the pathological features of AD and improve cognition in a variety of animal models. These preclinical studies have led to Phase 1 and 2 trials in different centers around the world. In this review, we present and interpret the pre-clinical evidence report some preliminary clinical data from a Phase 2 trial in early-stage AD patients. (c) 2023 by Radiation Research Society

引用

页码：506 / 516

页数：11

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