Directed Nickel-Catalyzed Selective Arylhydroxylation of Unactivated Alkenes under Air

被引：2
|
作者：
Wang, Yihua [1 ]
Lin, Cong [1 ]
Zhang, Zongxu [1 ]
Shen, Liang [2 ]
Zou, Boya [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Coll Chem & Chem Engn, Nanchang 330013, Peoples R China
[2] Jiangxi Sci & Technol Normal Univ, Coll Chem & Chem Engn, Jiangxi Engn Lab Waterborne Coatings, Nanchang 330013, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 13期
基金：
中国国家自然科学基金;
关键词：
ARYLBORONIC ACIDS; OXYARYLATION; FUNCTIONALIZATION; COMPLEXES; OXINDOLES; DIOXYGEN; STYRENES; OLEFINS; ACCESS;
D O I：
10.1021/acs.orglett.3c00085
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expeditious and novel nickel-catalyzed selective arylhydroxylation of unactivated alkenes with arylboronic acids was developed. This protocol is compatible with fi,y- and y,(5-alkene amides, including traditionally challenging internal alkenes, to provide important fi-arylethylalcohol scaffolds. The free hydroxyl group in the final product could be smoothly further transformed into other functional groups. Control experiments indicated that the oxygen atom of the hydroxyl group in the product is derived from the oxygen in the air.
引用
收藏
页码：2172 / 2177
页数：6
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