Nickel-Catalyzed Asymmetric Reductive Arylbenzylation of Unactivated Alkenes

被引：53
|
作者：
Jin, Youxiang [1 ]
Yang, Haobo [2 ]
Wang, Chuan [1 ]
机构：
[1] Univ Sci & Technol China, Ctr Excellence Mol Synth, Dept Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 07期
基金：
中国国家自然科学基金;
关键词：
VICINAL-DIARYLATION; COUPLING REACTIONS; ARYL-ALKENYLATION; ALKYL BROMIDES; HALIDES; DICARBOFUNCTIONALIZATION; STYRENES; DIFUNCTIONALIZATION; CYCLIZATION; OLEFINS;
D O I：
10.1021/acs.orglett.0c00688
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report a nickel-catalyzed asymmetric two-component reductive dicarbofunctionalization of aryl iodide-tethered unactivated alkenes using benzyl chlorides as the challenging coupling partner. This arylbenzylation reaction enables the efficient synthesis of diverse benzene-fused cyclic compounds bearing a quaternary stereocenter with a high tolerance of sensitive functionalities in highly enantioselective manner. The preliminary mechanistic investigations suggest a radical chain reaction mechanism.
引用
收藏
页码：2724 / 2729
页数：6
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