Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates

被引：31

作者：

Huang, David ^{[1
]}

Olivieri, Diego ^{[1
]}

Sun, Yang ^{[1
]}

Zhang, Pengpeng ^{[1
]}

Newhouse, Timothy R. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 41期

基金：

瑞士国家科学基金会;

关键词：

INTRAMOLECULAR HYDROALKYLATION; COUPLING REACTIONS; REDUCTIVE DICARBOFUNCTIONALIZATION; ALKYL BROMIDES; OLEFINS; METAL; ZINC; EFFICIENT; CYCLIZATION; REAGENTS;

D O I：

10.1021/jacs.9b09245

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.

引用

页码：16249 / 16254

页数：6

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