Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

被引：1
|
作者：
Zhang, Xiao-Fang [1 ]
Du, Jiao-Xian [1 ]
Teng, Si-Qiong [1 ]
Liu, Hui [1 ]
He, Juan [1 ,2 ]
Feng, Tao [1 ,2 ,3 ]
Liu, Ji-Kai [1 ,2 ]
机构：
[1] South Cent Minzu Univ, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Peoples R China
[2] South Cent Minzu Univ, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan 430074, Peoples R China
[3] South Cent Minzu Univ, Coll Life Sci, Wuhan 430074, Peoples R China
来源：
RSC ADVANCES | 2024年 / 14卷 / 16期
基金：
中国国家自然科学基金;
关键词：
SESQUITERPENE LACTONES; SEEDS;
D O I：
10.1039/d4ra00292j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Carpesabrolide A (1), featuring an unprecedented fumaric acid-guaiane sesquiterpenoid hybrid, has been isolated from the folk medicinal plant Carpesium abrotanoides. The structure with absolute configuration has been established by spectroscopic methods and single crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1 is proposed. Compound 1 shows significant anti-inflammatory activity by inhibiting NO production with an IC50 value of 2.7 mu M.
引用
收藏
页码：11002 / 11006
页数：5
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