Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

被引：1

作者：

Zhang, Xiao-Fang ^{[1
]}

Du, Jiao-Xian ^{[1
]}

Teng, Si-Qiong ^{[1
]}

Liu, Hui ^{[1
]}

He, Juan ^{[1
,2
]}

Feng, Tao ^{[1
,2
,3
]}

Liu, Ji-Kai ^{[1
,2
]}

机构：

[1] South Cent Minzu Univ, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Peoples R China

[2] South Cent Minzu Univ, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan 430074, Peoples R China

[3] South Cent Minzu Univ, Coll Life Sci, Wuhan 430074, Peoples R China

来源：

RSC ADVANCES | 2024年 / 14卷 / 16期

基金：

中国国家自然科学基金;

关键词：

SESQUITERPENE LACTONES; SEEDS;

D O I：

10.1039/d4ra00292j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carpesabrolide A (1), featuring an unprecedented fumaric acid-guaiane sesquiterpenoid hybrid, has been isolated from the folk medicinal plant Carpesium abrotanoides. The structure with absolute configuration has been established by spectroscopic methods and single crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1 is proposed. Compound 1 shows significant anti-inflammatory activity by inhibiting NO production with an IC50 value of 2.7 mu M.

引用

页码：11002 / 11006

页数：5

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