A five-component one-pot synthesis of phosphatidylinositol pentamannoside（PIM5）

被引：1

作者：

Dong Wang ^{[1
]}

De-Cai Xiong ^{[1
]}

Xin-Shan Ye ^{[1
]}

机构：

[1] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University

来源：

Chinese Chemical Letters | 2018年 / 29卷 / 09期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Phosphatidylinositol pentamannoside; Glycosylation; Preactivation; One-pot synthesis; Thioglycoside;

D O I：

暂无

中图分类号：

O629.13 [糖苷];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient synthesis of phosphatidylinositol pentamannoside（PIM;） was achieved based on a five-component one-pot sequential glycosylation protocol with exclusive regio-and stereo-selectivity.Two regioselective sequential glycosylations on inositol and p-tolyl thioglycosides as the sole type of building blocks made this protocol to avoid the tedious protective group manipulations. This synthetic strategy provides access to other important glycolipids with similar structures.

引用

页码：1340 / 1342

页数：3

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