Acidic ionic liquids catalyzed one-pot, pseudo five-component, and diastereoselective synthesis of highly functionalized piperidine derivatives

被引：38

作者：

Shaterian, Hamid Reza ^{[1
]}

Azizi, Kobra ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, Zahedan, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2013年 / 180卷

关键词：

Piperidine; Anilines; Aldehydes; beta-Ketoester; Ionic liquid; Catalyst; EFFICIENT SYNTHESIS; SCAFFOLDS; ATOM;

D O I：

10.1016/j.molliq.2013.01.020

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient and one-pot quantitative procedure for the preparation of functionalized piperidine derivatives from pseudo five-component reactions of aromatic aldehydes, substituted anilines, and ethyl/methyl acetoacetate (molar ratio: 2/2/1) in the presence of acidic ionic liquids such as 1-methylimidazolium hydrogen sulfate ([Hmim]HSO4), 1,1,3,3-tetramethylguanidinium perchlorate ([TMG]ClO4), and 1,1,3,3-tetramethylguanidinium trifluoroacetate ([TMG]TFA) as the catalysts has been developed. The ionic liquids were stable during the reaction process and could also be reused several times without significant loss of their activities. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：187 / 191

页数：5

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