An Efficient One-Pot Five-Component Tandem Sequential Approach for the Synthesis of Pyranopyrazole Derivatives via Suzuki Coupling and Multicomponent Reaction

被引：20

作者：

Lu, Zhangxiu ^{[1
]}

Xiao, Jinlong ^{[1
]}

Wang, Dongyang ^{[1
]}

Li, Yiqun ^{[1
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 4卷 / 05期

基金：

中国国家自然科学基金;

关键词：

arylboronic acids; multicomponent reactions; pyranopyrazoles; Suzuki coupling; tandem reactions; HETEROCYCLIC-COMPOUNDS; ORGANIC-SYNTHESIS; NOBEL-PRIZE; CATALYST; CASCADE; CONDENSATION; 4-COMPONENT; METAL;

D O I：

10.1002/ajoc.201500039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot tandem sequential protocol for efficient synthesis of a series of new pyranopyrazole derivatives has been developed involving Suzuki coupling of 4-bromobenzaldehyde and arylboronic acids followed by a four-component reaction from readily available ethyl acetoacetate, malononitrile, and hydrazine hydrate. All of the products were fully characterized by melting point, FTIR, (HNMR)-H-1, and (CNMR)-C-13 spectroscopy, and HRMS. The structure of one of the products was further established by X-ray diffraction analysis. This method should provide a useful strategy for the construction of pyranopyrazole heterocycles.

引用

页码：487 / 492

页数：6

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