Iron-Catalyzed Miyaura Borylation of Aryl Chlorides and Triflates

被引：2

作者：

Daley-Dee, Patrick ^{[1
]}

Clarke, James ^{[2
,3
]}

Monfette, Sebastien ^{[4
]}

Bedford, Robin B. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, England

[2] Pfizer Inc, Pfizer Chem Res & Dev, Sandwich CT13 9NJ, Kent, England

[3] Pfizer Ireland Pharmaceut, Ballintaggart, Co Cork, Ireland

[4] Pfizer Inc, Pfizer Chem Res & Dev, Groton, CT 06340 USA

来源：

ORGANIC LETTERS | 2024年 / 27卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

EFFICIENT SYNTHESIS; HALIDES; ROUTE;

D O I：

10.1021/acs.orglett.4c04171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple aryl chlorides represent challenging substrates in iron-catalyzed borylation. A combination of Li[B(tBu)pin-Bpin] as the borylating reagent and a catalyst formed in situ from iron(II) triflate and the commercially available N-heterocyclic carbene ligand, IMes, gives significantly improved activity and a much broader scope than previously reported iron-based catalysts. Iron triflate is also a good precatalyst for the borylation of aryl triflates-a previously unreported transformation-and in these cases the IMes ligand is not required.

引用

页码：197 / 201

页数：5

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