Pd-Catalyzed Difluoromethylthiolation of Aryl Chlorides, Bromides and Triflates

被引：14

作者：

Wu, Jiang ^{[1
]}

Lu, Changhui ^{[1
]}

Lu, Long ^{[2
]}

Shen, Qilong ^{[1
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, Key Lab Organofluorine Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2018年 / 36卷 / 11期

基金：

中国国家自然科学基金;

关键词：

palladium; cross-coupling; fluorine; COUPLING REACTIONS; C-NUCLEOPHILES; DIFLUOROMETHYLATION; REAGENT; TRIFLUOROMETHYLTHIOLATION; THIOETHERS; CHEMISTRY; FLUORINE; ETHERS; DI;

D O I：

10.1002/cjoc.201800306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient Pd-catalyzed difluoromethylthiolation of aryl chlorides, bromides and triflates is described. A variety of aryl halides with common functional groups were difluoromethylthiolated in moderate to excellent yields. Furthermore, several natural, drug and material molecules containing an aryl chloride, bromide, and phenol unit were successfully difluoromethylthiolated, thus providing medicinal chemists a general method for late-stage difluoromethylthiolation of leading compounds.

引用

页码：1031 / 1034

页数：4

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