Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics

被引：197
|
作者：
Fors, Brett P. [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 36期
基金：
美国国家卫生研究院;
关键词：
AROMATIC-SUBSTITUTION; ARYLBORONIC ACIDS; AMINATION; NITRATION; LIGANDS; SALTS;
D O I：
10.1021/ja905768k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient Pd catalyst for the transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics has been developed. This reaction proceeds under weakly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows for the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols. Mechanistic insight into the transmetalation step of the catalytic process is also reported.
引用
收藏
页码：12898 / +
页数：3
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