A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows

被引：0
|
作者：
George Clarke [1 ]
Jingwen Mao [2 ]
Angus Hann [3 ]
Yiyu Fan [2 ]
Amita Gupta [3 ]
Anisa Nutu [1 ]
Erwin Buckel Schaffner [2 ]
Kayani Kayani [3 ]
Nicholas Murphy [2 ]
Mansoor N. Bangash [3 ]
Anna L. Casey [4 ]
Isla Wootton [1 ]
Alexander J. Lawson [1 ]
Bobby V. M. Dasari [2 ]
M. Thamara P. R. Perera [3 ]
Hynek Mergental [5 ]
Simon C. Afford [6 ]
机构：
[1] Queen Elizabeth Hospital Birmingham,Liver Unit
[2] University of Birmingham and University Hospitals Birmingham NHS Foundation Trust,Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR)
[3] Institute of Immunology and Immunotherapy,Centre for Liver and Gastrointestinal Research
[4] University of Birmingham,Intensive Care Unit
[5] Ochre-Bio Ltd,Birmingham Acute Care Research Group
[6] Queen Elizabeth Hospital Birmingham,Microbiology Department
[7] Queen Elizabeth Hospital Birmingham,Clinical Biochemistry
[8] Institute of Inflammation and Ageing,undefined
[9] University of Birmingham,undefined
[10] Queen Elizabeth Hospital Birmingham,undefined
[11] Queen Elizabeth Hospital Birmingham,undefined
来源：
Communications Medicine | / 4卷 / 1期
关键词：
D O I：
10.1038/s43856-024-00636-2
中图分类号：
学科分类号：
摘要：
Clarke et al. present a reproducible protocol for the extended normothermic machine perfusion of human livers. Function and are preserved in five human livers perfused between 121–184 h.
引用
收藏
相关论文
共 50 条
  • [41] Successful ex-vivo normothermic machine perfusion and viability testing of discarded human donor livers
    den Dries, Sanna Op
    Karimian, Negin
    Sutton, Michael E.
    Westerkamp, Andrie
    Nijsten, Maarten
    Gouw, Annette S.
    Wiersema-Buist, Janneke
    Lisman, Ton
    Leuvenink, Henri G.
    Porte, Robert J.
    HEPATOLOGY, 2012, 56 (06) : 1527 - 1527
  • [42] Quality assessment of discarded human kidneys: a comparison of hypothermic machine perfusion and ex-vivo normothermic perfusion techniques
    Hosgood, S.
    Barlow, A.
    Nicholson, M.
    BRITISH JOURNAL OF SURGERY, 2016, 103 : 26 - 26
  • [43] Heart transplantation following medically assisted dying using ex-vivo normothermic machine perfusion
    O'Leary, Michael
    Joshi, Yashutosh
    Lewis, Kelly
    Fritis-Lamora, Rodrigo
    Soto, Claudio
    Macdonald, Peter S.
    TRANSPLANTATION, 2024, 108 (09) : 510 - 510
  • [44] Performance of Aged Liver Grafts in a Rat Model of Normothermic Ex Vivo Liver Machine Perfusion
    Moosburner, S.
    Zimmer, M.
    Gassner, J. M.
    Roschke, N.
    Berndt, N.
    Michelotto, J.
    Hillebrandt, K. H.
    Pratschke, J.
    Sauer, I. M.
    Raschzok, N.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 : 754 - 754
  • [45] Liver splitting during normothermic machine perfusion: a novel method to combine the advantages of both in-situ and ex-vivo techniques
    Lau, Ngee-Soon
    Ly, Mark
    Dennis, Claude
    Ewenson, Kasper
    Ly, Hayden
    Huang, Joanna L.
    Cabanes-Creus, Marti
    Chanda, Sumon
    Wang, Chuanmin
    Lisowski, Leszek
    Liu, Ken
    Kench, James
    McCaughan, Geoffrey
    Crawford, Michael
    Pulitano, Carlo
    HPB, 2023, 25 (05) : 543 - 555
  • [46] ASSESSMENT OF MITOCHONDRIAL FUNCTION DURING PROLONGED EX VIVO LIVER NORMOTHERMIC MACHINE PERFUSION
    Hofmann, Julia
    Meszaros, Andras T.
    Buch, Madita
    Nardin, Florian
    Fodor, Margot
    Otarashvili, Giorgi
    Hermann, Martin
    Cardini, Benno
    Messner, Franka
    Gasteiger, Silvia
    Bogensperger, Christina
    Oberhuber, Rupert
    Resch, Thomas
    Weissenbacher, Annemarie
    Oefner, Dietmar
    Troppmair, Jakob
    Hautz, Theresa
    Schneeberger, Stefan
    TRANSPLANT INTERNATIONAL, 2021, 34 : 320 - 320
  • [47] Normothermic Ex Vivo Machine Perfusion for Liver Transplantation: A Systematic Review of Progress in Humans
    Risbey, Charles W. G.
    Pulitano, Carlo
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (11)
  • [48] Normothermic Ex-Vivo Kidney Perfusion Preservation Reliably Improves Marginal Graft Function Compared to Hypothermic Machine Perfusion
    Urbanellis, Peter
    Hamar, Matyas
    Kollmann, Dagmar
    Linares, Ivan
    Ganesh, Sujani
    John, Rohan
    Konvalinka, Ana
    Mucsi, Istvan
    Ghanekar, Anand
    Bagli, Darius
    Grant, David
    Robinson, Lisa
    Selzner, Markus
    AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 85 - 86
  • [49] NORMOTHERMIC EX-VIVO KIDNEY PERFUSION PRESERVATION RELIABLY IMPROVES MARGINAL GRAFT FUNCTION COMPARED TO HYPOTHERMIC MACHINE PERFUSION
    Urbanellis, Peter
    Linares, Ivan
    Kollmann, Dagmar
    Ganesh, Sujani
    Mazilescu, Laura
    Oquendo, Fabiola
    Wiebe, Aryne
    John, Rohan
    Mucsi, Istvan
    Ghanekar, Anand
    Bagli, Darius
    Konvalinka, Ana
    Robinson, Lisa
    Selzner, Markus
    TRANSPLANTATION, 2020, 104 (09) : S251 - S251
  • [50] Criteria for Viability Assessment of Discarded Human Donor Livers During Ex-Vivo Normothermic Machine Perfusion
    Karimian, N.
    Sutton, M.
    op den Dries, S.
    de Boer, M.
    Wiersema-Buist, J.
    Gouw, A.
    Leuvenink, H.
    Lisman, T.
    Porte, R.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 345 - 345
12345