A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows

被引：0

作者：

George Clarke ^{[1
]}

Jingwen Mao ^{[2
]}

Angus Hann ^{[3
]}

Yiyu Fan ^{[2
]}

Amita Gupta ^{[3
]}

Anisa Nutu ^{[1
]}

Erwin Buckel Schaffner ^{[2
]}

Kayani Kayani ^{[3
]}

Nicholas Murphy ^{[2
]}

Mansoor N. Bangash ^{[3
]}

Anna L. Casey ^{[4
]}

Isla Wootton ^{[1
]}

Alexander J. Lawson ^{[1
]}

Bobby V. M. Dasari ^{[2
]}

M. Thamara P. R. Perera ^{[3
]}

Hynek Mergental ^{[5
]}

Simon C. Afford ^{[6
]}

机构：

[1] Queen Elizabeth Hospital Birmingham,Liver Unit

[2] University of Birmingham and University Hospitals Birmingham NHS Foundation Trust,Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR)

[3] Institute of Immunology and Immunotherapy,Centre for Liver and Gastrointestinal Research

[4] University of Birmingham,Intensive Care Unit

[5] Ochre-Bio Ltd,Birmingham Acute Care Research Group

[6] Queen Elizabeth Hospital Birmingham,Microbiology Department

[7] Queen Elizabeth Hospital Birmingham,Clinical Biochemistry

[8] Institute of Inflammation and Ageing,undefined

[9] University of Birmingham,undefined

[10] Queen Elizabeth Hospital Birmingham,undefined

[11] Queen Elizabeth Hospital Birmingham,undefined

来源：

Communications Medicine | / 4卷 / 1期

关键词：

D O I：

10.1038/s43856-024-00636-2

中图分类号：

学科分类号：

摘要：

Clarke et al. present a reproducible protocol for the extended normothermic machine perfusion of human livers. Function and are preserved in five human livers perfused between 121–184 h.

引用

共 50 条

[21] An adaptable research platform for ex vivo normothermic machine perfusion of the liver
M. Magbagbeola
Z. L. Rai
K. Doyle
L. Lindenroth
G. Dwyer
A. Gander
A. Stilli
B. R. Davidson
D. Stoyanov
International Journal of Computer Assisted Radiology and Surgery, 2023, 18 : 1101 - 1108
[22] Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
Carlson, K.
Najmabadi, F.
Pavan-Guimaraes, J.
Burlingham, W. J.
Capitini, C. M.
Al-Adra, D. P.
AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 : 651 - 651
[23] Normothermic Perfusion of Extended Criteria Donor Kidneys Utilizing an Ex Vivo Machine
Hossain, M. A.
Bagul, A.
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (09) : 2501 - 2502
[24] Quality Assessment of Human Kidneys by Ex-vivo Normothermic Machine Perfusion prior to Transplantation
Hosgood, Sarah
Wilson, Colin
Callaghan, Christopher
Phillips, Benedict
Bates, Lucy
Nicholson, Michael
BRITISH JOURNAL OF SURGERY, 2024, 111
[25] Normothermic machine perfusion of donor-lungs ex-vivo: promoting clinical adoption
Gilmour, Jenny
Griffiths, Chelsea
Pither, Tom
Scott, William E.
Fisher, Andrew J.
CURRENT OPINION IN ORGAN TRANSPLANTATION, 2020, 25 (03) : 285 - 292
[26] DIRECT COMPARISON OF HYPOTHERMIC AND NORMOTHERMIC MACHINE PERFUSION IN A PORCINE EX-VIVO KIDNEY MODEL
Vallant, Natalie
Wolfhagen, Nienke
Sandhu, Bynvant
Pusey, Charles
Papalois, Vassilios
TRANSPLANT INTERNATIONAL, 2017, 30 : 9 - 9
[27] Comparison of hypothermic and normothermic pulsatile machine perfusion in an ex-vivo porcine kidney model
Vallant, Natalie
Tam, Frederick
Sandhu, Bynvant
Wolfhagen, Nienke
Papalois, Vassilios
TRANSPLANTATION, 2016, 100 (07) : S652 - S652
[28] Twenty-four hour ex-vivo normothermic machine perfusion in rat livers
Haque, Omar
Pendexter, Casie A.
Cronin, Stephanie E. J.
Raigani, Siavash
de Vries, Reiner J.
Yeh, Heidi
Markmann, James F.
Uygun, Korkut
TECHNOLOGY, 2020, 8 (1-2): : 27 - 36
[29] Effects of perfusion and vascular architecture on contrast dispersion: validation in ex-vivo porcine liver under machine perfusion
Turco, Simona
Keravnou, Christina
van Sloun, Ruud J. G.
Wijkstra, Hessel
Averkiou, Mike
Mischi, Massimo
2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2016,
[30] Thrombolytic Therapy During ex-vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury
Haque, Omar
Raigani, Siavash
Rosales, Ivy
Carroll, Cailah
Coe, Taylor M.
Baptista, Sofia
Yeh, Heidi
Uygun, Korkut
Delmonico, Francis L.
Markmann, James F.
FRONTIERS IN SURGERY, 2021, 8

← 1 2 3 4 5 →