A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows

被引：0

作者：

George Clarke ^{[1
]}

Jingwen Mao ^{[2
]}

Angus Hann ^{[3
]}

Yiyu Fan ^{[2
]}

Amita Gupta ^{[3
]}

Anisa Nutu ^{[1
]}

Erwin Buckel Schaffner ^{[2
]}

Kayani Kayani ^{[3
]}

Nicholas Murphy ^{[2
]}

Mansoor N. Bangash ^{[3
]}

Anna L. Casey ^{[4
]}

Isla Wootton ^{[1
]}

Alexander J. Lawson ^{[1
]}

Bobby V. M. Dasari ^{[2
]}

M. Thamara P. R. Perera ^{[3
]}

Hynek Mergental ^{[5
]}

Simon C. Afford ^{[6
]}

机构：

[1] Queen Elizabeth Hospital Birmingham,Liver Unit

[2] University of Birmingham and University Hospitals Birmingham NHS Foundation Trust,Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR)

[3] Institute of Immunology and Immunotherapy,Centre for Liver and Gastrointestinal Research

[4] University of Birmingham,Intensive Care Unit

[5] Ochre-Bio Ltd,Birmingham Acute Care Research Group

[6] Queen Elizabeth Hospital Birmingham,Microbiology Department

[7] Queen Elizabeth Hospital Birmingham,Clinical Biochemistry

[8] Institute of Inflammation and Ageing,undefined

[9] University of Birmingham,undefined

[10] Queen Elizabeth Hospital Birmingham,undefined

[11] Queen Elizabeth Hospital Birmingham,undefined

来源：

Communications Medicine | / 4卷 / 1期

关键词：

D O I：

10.1038/s43856-024-00636-2

中图分类号：

学科分类号：

摘要：

Clarke et al. present a reproducible protocol for the extended normothermic machine perfusion of human livers. Function and are preserved in five human livers perfused between 121–184 h.

引用

共 50 条

[31] Thrombolytic Therapy During Ex-Vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury
Haque, O.
Raigani, S.
Rosales, I.
Carroll, C.
Coe, T. M.
Baptista, S.
Yeh, H.
Uygun, K.
Markmann, J. F.
AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 : 555 - 556
[32] SMALL ANIMAL MODEL OF NORMOTHERMIC EX VIVO LIVER MACHINE PERFUSION FOR LIVER TRANSPLANTATION
Gassner, J. M. G. V.
Moosburner, S.
Noesser, M.
Strobl, F.
Michelotto, J.
Claussen, F.
Wyrwal, D.
Pratschke, J.
Sauer, I. M.
Raschzok, N.
TRANSPLANT INTERNATIONAL, 2019, 32 : 29 - 29
[33] Normothermic ex-vivo liver perfusion: where do we stand and where to reach?
Jayant, Kumar
Reccia, Isabella
Shapiro, A. M. James
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2018, 12 (10) : 1045 - 1058
[34] Alpha-1 Antitrypsin Reduces Liver Ischemia Reperfusion Injury during Ex-Vivo Normothermic Machine Perfusion
Detelich, D.
de Vries, R.
Carroll, C.
Stein, M.
Uygun, K.
Yeh, H.
Markmann, J.
AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 623 - 624
[35] An experimental rodent model for long-term ex-vivo normothermic machine perfusion of livers
Ly, M.
Babekuhl, D.
Yousif, P.
Wang, C.
Lau, N. -S.
Crawford, M.
Pulitano, C.
TRANSPLANTATION, 2023, 107 (09) : 284 - 285
[36] Successful Ex-Vivo Normothermic Machine Perfusion and Viability Testing of Discarded Human Donor Livers
op den Dries, S.
Karimian, N.
Sutton, M.
Westerkamp, A.
Nijsten, M.
Gouw, A.
Wiersema-Buist, J.
Lisman, T.
Leuvenink, H.
Porte, R.
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 : 519 - 519
[37] SUCCESSFUL EX-VIVO NORMOTHERMIC MACHINE PERFUSION AND VIABILITY TESTING OF DISCARDED HUMAN DONOR LIVERS
Op den Dries, Sanna
Karimian, Negin
Sutton, Michael E.
Westerkamp, Andrie C.
Nijsten, Maarten W. N.
Gouw, Annet S. H.
Wiersema-Buist, Janneke
Lisman, Ton
Leuvenink, Henri G. D.
Porte, Robert J.
TRANSPLANT INTERNATIONAL, 2013, 26 : 337 - 337
[38] Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion.
Raigani, S.
Karimian, N.
Huang, V.
Geerts, S.
Nagpal, S.
Uygun, K.
Yarmush, M.
Yeh, H.
AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 746 - 746
[39] Perfusion Dynamics and Metabolic Profi ling of Steatotic Human Livers Undergoing Ex-Vivo Normothermic Machine Perfusion
Raigani, Siavash
Karimian, Negin
Huang, Viola
Geerts, Sharon
Fontan, Fermin
Aburawi, Mohamed
Detelich, Danielle
Beijert, Irene
Porte, Robert
Uygun, Korkut
Markmann, James
Yarmush, Martin
Yeh, Heidi
AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 18 - 18
[40] QUALITY ASSESSMENT OF DISCARDED HUMAN KIDNEYS: A COMPARISON OF HYPOTHERMIC MACHINE PERFUSION AND EX-VIVO NORMOTHERMIC PERFUSION TECHNIQUES
Hosgood, S.
Nicholson, M.
TRANSPLANT INTERNATIONAL, 2016, 29 : 14 - 14

← 1 2 3 4 5 →