Kinetic measurements of membrane target level and on-cell binding of biotherapeutic antibodies using flow-cytometry

被引：0
|
作者：
Daniel T. Doty [1 ]
Mahua Roy [2 ]
Phanidhar Kukutla [3 ]
Nicholas Lucarelli [1 ]
Peter E. Struss [6 ]
Lindsay E. King [1 ]
Jeffrey R. Chabot [4 ]
Jatin Narula [1 ]
Hendrik Neubert [5 ]
Polina Goihberg [1 ]
机构：
[1] Pfizer Research and Development,Biomarkers and Biomeasures, Department of Pharmacokinetics, Dynamics and Metabolism
[2] Department of Pharmacokinetics,Translational Modeling and Simulation
[3] Dynamics and Metabolism,Present Address: College of Medicine, Department of Medicine
[4] Pfizer Research and Development,Present Address: Clinical and Translational Biomarkers, Translational Clinical Sciences
[5] Present Address: Clinical Pharmacology and Quantitative Pharmacology,undefined
[6] AstraZeneca,undefined
[7] University of Florida,undefined
[8] Present Address: BioLegend,undefined
[9] Present Address: Thinkhat Venture Studios Inc.,undefined
[10] Pfizer Research and Development,undefined
来源：
AAPS Open | / 11卷 / 1期
关键词：
Antibodies; Monoclonal; Mathematical models; Biotherapeutics; Target expression; Drug discovery;
D O I：
10.1186/s41120-025-00112-8
中图分类号：
学科分类号：
摘要：
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