Kinetic measurements of membrane target level and on-cell binding of biotherapeutic antibodies using flow-cytometry

被引：0

作者：

Daniel T. Doty ^{[1
]}

Mahua Roy ^{[2
]}

Phanidhar Kukutla ^{[3
]}

Nicholas Lucarelli ^{[1
]}

Peter E. Struss ^{[6
]}

Lindsay E. King ^{[1
]}

Jeffrey R. Chabot ^{[4
]}

Jatin Narula ^{[1
]}

Hendrik Neubert ^{[5
]}

Polina Goihberg ^{[1
]}

机构：

[1] Pfizer Research and Development,Biomarkers and Biomeasures, Department of Pharmacokinetics, Dynamics and Metabolism

[2] Department of Pharmacokinetics,Translational Modeling and Simulation

[3] Dynamics and Metabolism,Present Address: College of Medicine, Department of Medicine

[4] Pfizer Research and Development,Present Address: Clinical and Translational Biomarkers, Translational Clinical Sciences

[5] Present Address: Clinical Pharmacology and Quantitative Pharmacology,undefined

[6] AstraZeneca,undefined

[7] University of Florida,undefined

[8] Present Address: BioLegend,undefined

[9] Present Address: Thinkhat Venture Studios Inc.,undefined

[10] Pfizer Research and Development,undefined

来源：

AAPS Open | / 11卷 / 1期

关键词：

Antibodies; Monoclonal; Mathematical models; Biotherapeutics; Target expression; Drug discovery;

D O I：

10.1186/s41120-025-00112-8

中图分类号：

学科分类号：

摘要：

引用

共 50 条

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