Recent Advances of L-ornithine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum

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作者：
Wu, Xiao-Yu [1 ]
Guo, Xiao-Yan [1 ]
Zhang, Bin [1 ]
Jiang, Yan [1 ]
Ye, Bang-Ce [2 ]
机构：
[1] Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China
[2] Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
来源：
Frontiers in Bioengineering and Biotechnology | 2020年 / 7卷
关键词：
L-ornithine; a valuable non-protein amino acid; has a wide range of applications in the pharmaceutical and food industries. Currently; microbial fermentation is a promising; sustainable; and environment-friendly method to produce L-ornithine. However; the industrial production capacity of L-ornithine by microbial fermentation is low and rarely meets the market demands. Various strategies have been employed to improve the L-ornithine production titers in the model strain; Corynebacterium glutamicum; which serves as a major indicator for improving the cost-effectiveness of L-ornithine production by microbial fermentation. This review focuses on the development of high L-ornithine-producing strains by metabolic engineering and reviews the recent advances in breeding strategies; such as reducing by-product formation; improving the supplementation of precursor glutamate; releasing negative regulation and negative feedback inhibition; increasing the supply of intracellular cofactors; modulating the central metabolic pathway; enhancing the transport system; and adaptive evolution for improving L-ornithine production. © Copyright © 2020 Wu; Guo; Zhang; Jiang and Ye;
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